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alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Topić, Aleksandra | |
dc.creator | Spasić, S | |
dc.creator | Petrović, V | |
dc.date.accessioned | 2019-09-02T10:48:48Z | |
dc.date.available | 2019-09-02T10:48:48Z | |
dc.date.issued | 1994 | |
dc.identifier.issn | 0394-249X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/113 | |
dc.description.abstract | The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p lt 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed. | en |
dc.rights | restrictedAccess | |
dc.source | Gene geography : a computerized bulletin on human gene frequencies | |
dc.title | alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium. | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јелић-Ивановић, Зорана; Спасић, С; Спасојевић-Калимановска, Весна; Топиц, Aлександра; Петровић, В; | |
dc.citation.volume | 8 | |
dc.citation.issue | 2 | |
dc.citation.spage | 129 | |
dc.citation.epage | 135 | |
dc.citation.other | 8(2): 129-135 | |
dc.identifier.scopus | 2-s2.0-0028490551 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_113 | |
dc.type.version | publishedVersion |
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