Show simple item record

dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorTopić, Aleksandra
dc.creatorSpasić, S
dc.creatorPetrović, V
dc.date.accessioned2019-09-02T10:48:48Z
dc.date.available2019-09-02T10:48:48Z
dc.date.issued1994
dc.identifier.issn0394-249X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/113
dc.description.abstractThe distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p lt 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.en
dc.rightsrestrictedAccess
dc.sourceGene geography : a computerized bulletin on human gene frequencies
dc.titlealpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасић, С; Спасојевић-Калимановска, Весна; Топиц, Aлександра; Петровић, В;
dc.citation.volume8
dc.citation.issue2
dc.citation.spage129
dc.citation.epage135
dc.citation.other8(2): 129-135
dc.identifier.scopus2-s2.0-0028490551
dc.identifier.rcubconv_4587
dc.type.versionpublishedVersion


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record