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Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)

Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)

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2008
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Authors
Kundaković, Tatjana
Stanojković, Tatjana
Milenković, Marina
Grubin, Jasmina
Juranić, Zorica
Stevanović, Branka
Kovačević, Nada
Article (Published version)
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Abstract
Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity.
Cikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost.
Keywords:
cytotoxicity / antioxidant activity / antimicrobial activity / ampelopsis brevipedunculata / parthenocissus tricuspidata / vitaceae
Source:
Archives of Biological Sciences, 2008, 60, 4, 641-647
Publisher:
  • Srpsko biološko društvo, Beograd, i dr.
Projects:
  • Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-143012)
  • Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
  • Diversity of the flora and vegetation of the Central Balkans: Ecology, chorology, and conservation (RS-143015)

DOI: 10.2298/ABS0804641K

ISSN: 0354-4664

WoS: 000262112000017

Scopus: 2-s2.0-57749096180
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1141
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