Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)
Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)

2008
Authors
Kundaković, Tatjana
Stanojković, Tatjana

Milenković, Marina

Grubin, Jasmina
Juranić, Zorica
Stevanović, Branka
Kovačević, Nada

Article (Published version)
Metadata
Show full item recordAbstract
Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity.
Cikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost.
Keywords:
cytotoxicity / antioxidant activity / antimicrobial activity / ampelopsis brevipedunculata / parthenocissus tricuspidata / vitaceaeSource:
Archives of Biological Sciences, 2008, 60, 4, 641-647Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Projects:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-143012)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
- Diversity of the flora and vegetation of the Central Balkans: Ecology, chorology, and conservation (RS-143015)
DOI: 10.2298/ABS0804641K
ISSN: 0354-4664