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Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)

dc.creatorKundaković, Tatjana
dc.creatorStanojković, Tatjana
dc.creatorMilenković, Marina
dc.creatorGrubin, Jasmina
dc.creatorJuranić, Zorica
dc.creatorStevanović, Branka
dc.creatorKovačević, Nada
dc.date.accessioned2019-09-02T11:15:16Z
dc.date.available2019-09-02T11:15:16Z
dc.date.issued2008
dc.identifier.issn0354-4664
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1141
dc.description.abstractCyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity.en
dc.description.abstractCikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost.sr
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143015/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciences
dc.subjectcytotoxicityen
dc.subjectantioxidant activityen
dc.subjectantimicrobial activityen
dc.subjectampelopsis brevipedunculataen
dc.subjectparthenocissus tricuspidataen
dc.subjectvitaceaeen
dc.titleCytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)en
dc.titleCitotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)sr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтевановић, Бранка; Грубин, Јасмина; Јуранић, Зорица; Миленковић, Марина; Станојковић, Татјана; Ковачевић, Нада; Кундаковић, Татјана;
dc.citation.volume60
dc.citation.issue4
dc.citation.spage641
dc.citation.epage647
dc.citation.other60(4): 641-647
dc.identifier.wos000262112000017
dc.identifier.doi10.2298/ABS0804641K
dc.identifier.scopus2-s2.0-57749096180
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/109/1139.pdf
dc.identifier.rcubconv_882
dc.type.versionpublishedVersion


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