Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)
Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)
dc.creator | Kundaković, Tatjana | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Milenković, Marina | |
dc.creator | Grubin, Jasmina | |
dc.creator | Juranić, Zorica | |
dc.creator | Stevanović, Branka | |
dc.creator | Kovačević, Nada | |
dc.date.accessioned | 2019-09-02T11:15:16Z | |
dc.date.available | 2019-09-02T11:15:16Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1141 | |
dc.description.abstract | Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity. | en |
dc.description.abstract | Cikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost. | sr |
dc.publisher | Srpsko biološko društvo, Beograd, i dr. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143015/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Archives of Biological Sciences | |
dc.subject | cytotoxicity | en |
dc.subject | antioxidant activity | en |
dc.subject | antimicrobial activity | en |
dc.subject | ampelopsis brevipedunculata | en |
dc.subject | parthenocissus tricuspidata | en |
dc.subject | vitaceae | en |
dc.title | Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae) | en |
dc.title | Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae) | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Стевановић, Бранка; Грубин, Јасмина; Јуранић, Зорица; Миленковић, Марина; Станојковић, Татјана; Ковачевић, Нада; Кундаковић, Татјана; | |
dc.citation.volume | 60 | |
dc.citation.issue | 4 | |
dc.citation.spage | 641 | |
dc.citation.epage | 647 | |
dc.citation.other | 60(4): 641-647 | |
dc.identifier.wos | 000262112000017 | |
dc.identifier.doi | 10.2298/ABS0804641K | |
dc.identifier.scopus | 2-s2.0-57749096180 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/109/1139.pdf | |
dc.type.version | publishedVersion |