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Hromatografske metode za predviđanje apsorpcije leka posle oralne primene

dc.creatorČudina, Olivera
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:15:38Z
dc.date.available2019-09-02T11:15:38Z
dc.date.issued2008
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1156
dc.description.abstractToday with the development of combinatorial chemistry hundreds and hundreds of compounds that have potential biological activity are synthesized. The studies which include the selection of drug candidates and the study of their pharmacological properties are time consuming, expensive and usually require the use of experimental animals. For ethical and/or economical reasons, a great deal effort is currently being made to develop in vitro systems and provide primary information about the capability of new compounds in the first steps of drug development. Chromatographic models to predict drug absorption are experimentally easier than membrane-based permeability assays, because of their simplicity, accuracy and avoidance of experimental animals. Different chromatographic systems have been proposed to predict oral drug absorption. The use of conventional reversed-phase columns only has proven to provide adequate correlations for homologous series of compounds. The inclusion of amphiphilic structures in the stationary and/or mobile phases is a pre-requisite to emulate interactions of drugs with the phospholipids bilayers in the membranes.en
dc.description.abstractSavremeni razvoj kombinatorijalne hemije omogućio je sintezu velikog broja jedinjenja sa potencijalnom biološkom aktivnošću. Ispitivanja koja uključuju izbor jedinjenja i studije farmakoloških osobina su dugotrajna, skupa i obično zahtevaju primenu eksperimentalnih životinja. Iz etičkih i/ili ekonomskih razloga, veliki napori ulažu se u razvoj in vitro sistema koji mogu da pruže značajne informacije u ranim fazama razvoja leka. Hromatografski modeli za predviđanje apsorpcije leka su eksperimentalno jednostavni, tačni i ne zahtevaju primenu eksperimentalnih životinja. Primena reverznofaznih hromatografskih sistema dala je dobre korelacije samo za homologe serije jedinjenja. Uvođenje amfifilnih struktura u stacionarnu i/ili mobilnu fazu je bitan uslov za simulaciju interakcija farmakološki aktivnih jedinjenja sa fosfolipidnim dvoslojem u membrani.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectMicellar liquid chromatographyen
dc.subjectDrug absorptionen
dc.subjectBiopartition ingmicellar chromatographyen
dc.subjectMicelarna tečna hromatografijasr
dc.subjectapsorpcija lekasr
dc.subjectbioparticiona micelarna hromatografijasr
dc.titleChromatographic methods in predicting oral drug absorptionen
dc.titleHromatografske metode za predviđanje apsorpcije leka posle oralne primenesr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractВладимиров, Соте; Чудина, Оливера; Хроматографске методе за предвиђање апсорпције лека после оралне примене; Хроматографске методе за предвиђање апсорпције лека после оралне примене;
dc.citation.volume58
dc.citation.issue4
dc.citation.spage231
dc.citation.epage240
dc.citation.other58(4): 231-240
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/125/1154.pdf
dc.identifier.rcubconv_375
dc.type.versionpublishedVersion


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