The thrombotic tendency in anti phospholipid syndrome (APS) shares several pathways with atherosclerosis. Atherothrombosis (atherosclerosis superimposed with thromboses) is influenced by nonmodifiable and some modifiable risk factors (smoking, obesity, physical inactivity, alcohol abuse, hyperhomocysteinemia). Therefore, we investigated the association among clinical and serological features of patients with primary APS and potentially modifiable risk factors for the development of atherothrombosis. Also, we compared the analyzed parameters with those in control subjects. Homo cysteine concentrations were detected by HPLC (high performance liquid chromatography), while antiphospholipid antibodies were detected by ELISA. Smokers had elevated levels of homocysteine (chi(2) = 6.22, p lt 0.05). Independently of patients' age, the association between increased levels of homocysteine and history of myocardial infarctions was found (chi(2) = 4.61, p lt 0.05). Hyperhomocysteinemia and smok...ing are the most important modifiable risk factors for atherothrombosis in primary APS.
TY - JOUR
AU - Becarević, Mirjana
AU - Mirković, Duško
AU - Majkić-Singh, Nada
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1161
AB - The thrombotic tendency in anti phospholipid syndrome (APS) shares several pathways with atherosclerosis. Atherothrombosis (atherosclerosis superimposed with thromboses) is influenced by nonmodifiable and some modifiable risk factors (smoking, obesity, physical inactivity, alcohol abuse, hyperhomocysteinemia). Therefore, we investigated the association among clinical and serological features of patients with primary APS and potentially modifiable risk factors for the development of atherothrombosis. Also, we compared the analyzed parameters with those in control subjects. Homo cysteine concentrations were detected by HPLC (high performance liquid chromatography), while antiphospholipid antibodies were detected by ELISA. Smokers had elevated levels of homocysteine (chi(2) = 6.22, p lt 0.05). Independently of patients' age, the association between increased levels of homocysteine and history of myocardial infarctions was found (chi(2) = 4.61, p lt 0.05). Hyperhomocysteinemia and smoking are the most important modifiable risk factors for atherothrombosis in primary APS.
PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2 - Journal of Medical Biochemistry
T1 - Hyperhomocysteinemia and smoking in primary antiphospholipid syndrome
VL - 28
IS - 3
SP - 172
EP - 175
DO - 10.2478/v10011-009-0019-6
ER -
@article{
author = "Becarević, Mirjana and Mirković, Duško and Majkić-Singh, Nada",
year = "2009",
abstract = "The thrombotic tendency in anti phospholipid syndrome (APS) shares several pathways with atherosclerosis. Atherothrombosis (atherosclerosis superimposed with thromboses) is influenced by nonmodifiable and some modifiable risk factors (smoking, obesity, physical inactivity, alcohol abuse, hyperhomocysteinemia). Therefore, we investigated the association among clinical and serological features of patients with primary APS and potentially modifiable risk factors for the development of atherothrombosis. Also, we compared the analyzed parameters with those in control subjects. Homo cysteine concentrations were detected by HPLC (high performance liquid chromatography), while antiphospholipid antibodies were detected by ELISA. Smokers had elevated levels of homocysteine (chi(2) = 6.22, p lt 0.05). Independently of patients' age, the association between increased levels of homocysteine and history of myocardial infarctions was found (chi(2) = 4.61, p lt 0.05). Hyperhomocysteinemia and smoking are the most important modifiable risk factors for atherothrombosis in primary APS.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Hyperhomocysteinemia and smoking in primary antiphospholipid syndrome",
volume = "28",
number = "3",
pages = "172-175",
doi = "10.2478/v10011-009-0019-6"
}
Becarević, M., Mirković, D.,& Majkić-Singh, N.. (2009). Hyperhomocysteinemia and smoking in primary antiphospholipid syndrome. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 28(3), 172-175.
https://doi.org/10.2478/v10011-009-0019-6
Becarević M, Mirković D, Majkić-Singh N. Hyperhomocysteinemia and smoking in primary antiphospholipid syndrome. in Journal of Medical Biochemistry. 2009;28(3):172-175.
doi:10.2478/v10011-009-0019-6 .
Becarević, Mirjana, Mirković, Duško, Majkić-Singh, Nada, "Hyperhomocysteinemia and smoking in primary antiphospholipid syndrome" in Journal of Medical Biochemistry, 28, no. 3 (2009):172-175,
https://doi.org/10.2478/v10011-009-0019-6 . .
