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dc.creatorIvić, Branka
dc.creatorIbrić, Svetlana
dc.creatorBetz, Gabriele
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T11:15:46Z
dc.date.available2019-09-02T11:15:46Z
dc.date.issued2009
dc.identifier.issn0031-6903
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1162
dc.description.abstractThe purpose of the study was to screen the effects of formulation factors on the in vitro release profile of diclofenac sodium from matrix pellets compressed into multiple unit pellet system (MUPS) tablets using design of experiment (DOE). Extended release of diclofenac sodium was accomplished using Carbopol (R) 71G as matrix substance. According to Fractional Factorial Design FFD 2(3-1) four formulations of diclofenac sodium MUPS matrix tablets were prepared. The process of direct pelletization and subsequently compression of the pellets into tablets was applied in order to investigate a different approach in formulation of matrix systems and to achieve a better control of the process factors over the principal response - the release of the drug. The investigated factors were X-1-the percentage of polymer Carbopol (R) 71G, X-2-crushing strength of the tablet and X-3-different batches of the diclofenac sodium. In vitro dissolution time profiles at 6 different sampling times were chosen as responses. Results of drug release studies indicated that drug release rates vary between different formulations, with a range of 1 to 8 h to complete dissolution. The most important impact on the drug release hart factor X-1-the percentage of polymer Carbopol (R) 71G. The polymer percentage is suggested as release regulator for diclofenac sodium release from MUPS matrix tablets. All other investigated factors had no significant influence on the release profile of diclofenac sodium.en
dc.publisherPharmaceutical Soc Japan, Tokyo
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/23015/RS//
dc.rightsopenAccess
dc.sourceZdravstveno varstvo
dc.subjectmatrix pelleten
dc.subjectdirect pelletizationen
dc.subjectdiclofenac sodiumen
dc.subjectCarbopol (R) 71Gen
dc.subjectmultiple unit pellet system (MUPS)en
dc.subjectdesign of experimentsen
dc.titleEvaluation of Diclofenac Sodium Release from Matrix Pellets Compressed into MUPS Tabletsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂурић, Зорица; Бетз, Габриеле; Ибрић, Светлана; Ивић, Бранка;
dc.citation.volume129
dc.citation.issue11
dc.citation.spage1375
dc.citation.epage1384
dc.citation.other129(11): 1375-1384
dc.citation.rankM23
dc.identifier.wos000271247500014
dc.identifier.doi10.1248/yakushi.129.1375
dc.identifier.pmid19881210
dc.identifier.scopus2-s2.0-70450161335
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/131/1160.pdf
dc.identifier.rcubconv_2240
dc.type.versionpublishedVersion


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