Приказ основних података о документу
Isoelectrofocusing and PCR Amplification-Reverse Hybridization Assay in Evaluation of Alpha-1-Antitrypsin Deficiency
dc.creator | Beletić, Anđelo | |
dc.creator | Đorđević, Valentina | |
dc.creator | Dudvarski-Ilić, Aleksandra | |
dc.creator | Obradović, Ivana | |
dc.creator | Mirković, Duško | |
dc.creator | Ilić, Mirka | |
dc.creator | Radojković, Dragica | |
dc.creator | Majkić-Singh, Nada | |
dc.date.accessioned | 2019-09-02T11:15:50Z | |
dc.date.available | 2019-09-02T11:15:50Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1163 | |
dc.description.abstract | Alpha-1-antitrypsin deficiency is a potentially lethal genetic disorder, which has pulmonary and liver manifestations. The standardized biochemical and molecular diagnostic protocol for detection of clinically relevant alleles is needed. The paper summarizes current concepts about AATD, describes the potentials of isoelectric focusing and PCR amplification-reverse allele specific oligonucleotide hybridization assay in the detection of affected individuals and shortly presents our experiences in the evaluation of AATD. We conclude that the systematic clinical laboratory approach to AATD might be based on the combination of mentioned methods, coordinated by alpha-1-antritrypsin quantification. Additionally, its complete medical implementation is achieved through teamwork between clinical chemists, molecular biologists and clinicians. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije, Beograd i Versita | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145010/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Medical Biochemistry | |
dc.subject | isoelectrofocusing | en |
dc.subject | PCR-reverse hybridization | en |
dc.subject | alpha-1-antitrypsin | en |
dc.title | Isoelectrofocusing and PCR Amplification-Reverse Hybridization Assay in Evaluation of Alpha-1-Antitrypsin Deficiency | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђорђевић, Валентина; Дудварски-Илић, Aлександра; Радојковић, Драгица; Мирковић, Душко; Илић, Мирка; Мајкић-Сингх, Нада; Белетић, Aнђело; Обрадовић, Ивана; | |
dc.citation.volume | 28 | |
dc.citation.issue | 4 | |
dc.citation.spage | 241 | |
dc.citation.epage | 247 | |
dc.citation.other | 28(4): 241-247 | |
dc.citation.rank | M52 | |
dc.identifier.wos | 000271039600004 | |
dc.identifier.doi | 10.2478/v10011-009-0023-x | |
dc.identifier.scopus | 2-s2.0-70449403475 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/132/1161.pdf | |
dc.type.version | publishedVersion |