Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction
2009
Преузимање 🢃
Аутори
Beletić, AnđeloMirković, Duško
Antonijević, Nebojša
Đorđević, Valentina
Sango, Violeta
Jakovljević, Branko
Perunicić, Jovan
Ilić, Mirka
Vasiljević, Zorana
Majkić-Singh, Nada
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Hyperhomocysteinemia is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR C677T reduces the activity of methylenetetra-hydrofolatereductase and may cause hyperhomocysteinemia. Incidence of hyperhomocysteinemia (homocysteine above 12 mu mol/L), homocysteine level, and distribution of MTHFR C677T genotypes (C/C, C/T and T/T) are T/T) are compared between young patients with acute myocardial infarction and healthy persons, matched by age. Study involved 86 patients younger than 45 years (77 men and 9 women) and 35 controls. Homocysteine was measured by an HPLC method and the MTHFR C677T genotype determined using PCR amplification and digestion with Hinf I. Statistical analyses included chisquare and Mann-Whitney U tests. Hyperhomocysteinemia was present in 32.6% patients and 14.3% controls, revealing a significant difference (P = 0.038). Median homocysteine levels in patients (10.4 mu mol/L) and controls (9.6 mu mol/L) were significantly different ...(P=0.035). Among patients, 50.0% had C/C, 41.9% C/T and 8.1% T/T genotype, and the genotype had no influence on hyperhomocysteinemia incidence and homocysteine level. Genotype distribution in patients was not significantly different from the observed in controls. The conclusion is that young patients with acute myocardial infarction have higher incidence of hyperhomocysteinemia and higher homocysteine levels than healthy young adults, while there is no significant difference in the distribution of MTHFR C677T genotypes.
Кључне речи:
hyperhomocysteinemia / MTHFR / myocardial infarction / young adultsИзвор:
Journal of Medical Biochemistry, 2009, 28, 1, 41-45Издавач:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Финансирање / пројекти:
- Биохемијски показатељи оштећења и дисфункције органа (RS-MESTD-MPN2006-2010-145010)
DOI: 10.2478/v10011-008-0029-9
ISSN: 1452-8258
WoS: 000270010700007
Scopus: 2-s2.0-60249088201
Институција/група
PharmacyTY - JOUR AU - Beletić, Anđelo AU - Mirković, Duško AU - Antonijević, Nebojša AU - Đorđević, Valentina AU - Sango, Violeta AU - Jakovljević, Branko AU - Perunicić, Jovan AU - Ilić, Mirka AU - Vasiljević, Zorana AU - Majkić-Singh, Nada PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1168 AB - Hyperhomocysteinemia is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR C677T reduces the activity of methylenetetra-hydrofolatereductase and may cause hyperhomocysteinemia. Incidence of hyperhomocysteinemia (homocysteine above 12 mu mol/L), homocysteine level, and distribution of MTHFR C677T genotypes (C/C, C/T and T/T) are T/T) are compared between young patients with acute myocardial infarction and healthy persons, matched by age. Study involved 86 patients younger than 45 years (77 men and 9 women) and 35 controls. Homocysteine was measured by an HPLC method and the MTHFR C677T genotype determined using PCR amplification and digestion with Hinf I. Statistical analyses included chisquare and Mann-Whitney U tests. Hyperhomocysteinemia was present in 32.6% patients and 14.3% controls, revealing a significant difference (P = 0.038). Median homocysteine levels in patients (10.4 mu mol/L) and controls (9.6 mu mol/L) were significantly different (P=0.035). Among patients, 50.0% had C/C, 41.9% C/T and 8.1% T/T genotype, and the genotype had no influence on hyperhomocysteinemia incidence and homocysteine level. Genotype distribution in patients was not significantly different from the observed in controls. The conclusion is that young patients with acute myocardial infarction have higher incidence of hyperhomocysteinemia and higher homocysteine levels than healthy young adults, while there is no significant difference in the distribution of MTHFR C677T genotypes. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction VL - 28 IS - 1 SP - 41 EP - 45 DO - 10.2478/v10011-008-0029-9 ER -
@article{ author = "Beletić, Anđelo and Mirković, Duško and Antonijević, Nebojša and Đorđević, Valentina and Sango, Violeta and Jakovljević, Branko and Perunicić, Jovan and Ilić, Mirka and Vasiljević, Zorana and Majkić-Singh, Nada", year = "2009", abstract = "Hyperhomocysteinemia is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR C677T reduces the activity of methylenetetra-hydrofolatereductase and may cause hyperhomocysteinemia. Incidence of hyperhomocysteinemia (homocysteine above 12 mu mol/L), homocysteine level, and distribution of MTHFR C677T genotypes (C/C, C/T and T/T) are T/T) are compared between young patients with acute myocardial infarction and healthy persons, matched by age. Study involved 86 patients younger than 45 years (77 men and 9 women) and 35 controls. Homocysteine was measured by an HPLC method and the MTHFR C677T genotype determined using PCR amplification and digestion with Hinf I. Statistical analyses included chisquare and Mann-Whitney U tests. Hyperhomocysteinemia was present in 32.6% patients and 14.3% controls, revealing a significant difference (P = 0.038). Median homocysteine levels in patients (10.4 mu mol/L) and controls (9.6 mu mol/L) were significantly different (P=0.035). Among patients, 50.0% had C/C, 41.9% C/T and 8.1% T/T genotype, and the genotype had no influence on hyperhomocysteinemia incidence and homocysteine level. Genotype distribution in patients was not significantly different from the observed in controls. The conclusion is that young patients with acute myocardial infarction have higher incidence of hyperhomocysteinemia and higher homocysteine levels than healthy young adults, while there is no significant difference in the distribution of MTHFR C677T genotypes.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction", volume = "28", number = "1", pages = "41-45", doi = "10.2478/v10011-008-0029-9" }
Beletić, A., Mirković, D., Antonijević, N., Đorđević, V., Sango, V., Jakovljević, B., Perunicić, J., Ilić, M., Vasiljević, Z.,& Majkić-Singh, N.. (2009). Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 28(1), 41-45. https://doi.org/10.2478/v10011-008-0029-9
Beletić A, Mirković D, Antonijević N, Đorđević V, Sango V, Jakovljević B, Perunicić J, Ilić M, Vasiljević Z, Majkić-Singh N. Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction. in Journal of Medical Biochemistry. 2009;28(1):41-45. doi:10.2478/v10011-008-0029-9 .
Beletić, Anđelo, Mirković, Duško, Antonijević, Nebojša, Đorđević, Valentina, Sango, Violeta, Jakovljević, Branko, Perunicić, Jovan, Ilić, Mirka, Vasiljević, Zorana, Majkić-Singh, Nada, "Incidence of hyperhomocysteinemia and Mthfr C677T polymorphism among young patients with acute myocardial infarction" in Journal of Medical Biochemistry, 28, no. 1 (2009):41-45, https://doi.org/10.2478/v10011-008-0029-9 . .