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Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture
dc.creator | Ninković, Milica | |
dc.creator | Maliević, Ivorad M. | |
dc.creator | Jelenković, Ankica V. | |
dc.creator | Đukić, Mirjana | |
dc.creator | Jovanović, Marina | |
dc.creator | Stevanović, Ivana | |
dc.date.accessioned | 2019-09-02T11:16:02Z | |
dc.date.available | 2019-09-02T11:16:02Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0231-5882 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1169 | |
dc.description.abstract | Oxidative stress development in different brain structures and the influence of nitric oxide (NO) overproduction during sepsis was investigated using male Wistar rats. Rats were subjected to cecal ligation and puncture (CLP) or were sham-operated. To evaluate the source of NO production, 30 min before the operation septic and control animals were treated with single intraperitoneal doses of NO synthase (NOS) inhibitors: L-NAME and aminoguanidine (AG) (10, 30 or 90 mg/kg) and 7-nitroindazole (7-NI) (30 mg/kg). The concentration of GSH in the cortex, brain stem, cerebellum, striatum and hippocampus significantly decreased post CLP at both early and late stage sepsis. Lipid peroxidation also occurred in the cortex and cerebellum in late stage sepsis. Pre-treatment with a non-selective NOS inhibitor (L-NAME) and with selective inducible and neuronal NOS inhibitors (AG and 7-NI) revealed benefit effects on the GSH concentrations. Unexpectedly, NOS inhibition resulted in diverse effects on TBARS concentrations, suggesting the importance of specific quantities of NO in specific brain structures during sepsis. | en |
dc.publisher | General Physiol And Biophysics, Bratislava | |
dc.relation | Military Medical Academy, Serbia - VMA/08-10/B.3 | |
dc.rights | restrictedAccess | |
dc.source | General Physiology and Biophysics | |
dc.subject | Sepsis | en |
dc.subject | Brain | en |
dc.subject | Nitric oxide synthase inhibitors | en |
dc.subject | Rat | en |
dc.title | Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђукић, Мирјана; Малиевић, Иворад М.; Јовановић, Марина; Нинковић, Милица; Стевановић, Ивана Д.; Јеленковић, Aнкица В.; | |
dc.citation.volume | 28 | |
dc.citation.spage | 243 | |
dc.citation.epage | 250 | |
dc.citation.other | 28: 243-250 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000208112300035 | |
dc.identifier.pmid | 19893107 | |
dc.identifier.scopus | 2-s2.0-77649245096 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1476 | |
dc.type.version | publishedVersion |
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