The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain
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Stevanović, Nana D.Jovanović, Marina
Jelenković, Ankica V.
Ninković, Milica
Đukić, Mirjana

Stojanović, Ivana
Čolić, Miodrag

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The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.
Keywords:
Aluminium / L-NAME / Nitric oxide / Oxidative stress / StriatumSource:
General Physiology and Biophysics, 2009, 28, 235-242Publisher:
- General Physiol And Biophysics, Bratislava
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PharmacyTY - JOUR AU - Stevanović, Nana D. AU - Jovanović, Marina AU - Jelenković, Ankica V. AU - Ninković, Milica AU - Đukić, Mirjana AU - Stojanović, Ivana AU - Čolić, Miodrag PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1182 AB - The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity. PB - General Physiol And Biophysics, Bratislava T2 - General Physiology and Biophysics T1 - The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain VL - 28 SP - 235 EP - 242 UR - https://hdl.handle.net/21.15107/rcub_farfar_1182 ER -
@article{ author = "Stevanović, Nana D. and Jovanović, Marina and Jelenković, Ankica V. and Ninković, Milica and Đukić, Mirjana and Stojanović, Ivana and Čolić, Miodrag", year = "2009", abstract = "The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.", publisher = "General Physiol And Biophysics, Bratislava", journal = "General Physiology and Biophysics", title = "The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain", volume = "28", pages = "235-242", url = "https://hdl.handle.net/21.15107/rcub_farfar_1182" }
Stevanović, N. D., Jovanović, M., Jelenković, A. V., Ninković, M., Đukić, M., Stojanović, I.,& Čolić, M.. (2009). The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain. in General Physiology and Biophysics General Physiol And Biophysics, Bratislava., 28, 235-242. https://hdl.handle.net/21.15107/rcub_farfar_1182
Stevanović ND, Jovanović M, Jelenković AV, Ninković M, Đukić M, Stojanović I, Čolić M. The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain. in General Physiology and Biophysics. 2009;28:235-242. https://hdl.handle.net/21.15107/rcub_farfar_1182 .
Stevanović, Nana D., Jovanović, Marina, Jelenković, Ankica V., Ninković, Milica, Đukić, Mirjana, Stojanović, Ivana, Čolić, Miodrag, "The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain" in General Physiology and Biophysics, 28 (2009):235-242, https://hdl.handle.net/21.15107/rcub_farfar_1182 .