The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.
TY - JOUR
AU - Stevanović, Nana D.
AU - Jovanović, Marina
AU - Jelenković, Ankica V.
AU - Ninković, Milica
AU - Đukić, Mirjana
AU - Stojanović, Ivana
AU - Čolić, Miodrag
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1182
AB - The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.
PB - General Physiol And Biophysics, Bratislava
T2 - General Physiology and Biophysics
T1 - The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain
VL - 28
SP - 235
EP - 242
UR - https://hdl.handle.net/21.15107/rcub_farfar_1182
ER -
@article{
author = "Stevanović, Nana D. and Jovanović, Marina and Jelenković, Ankica V. and Ninković, Milica and Đukić, Mirjana and Stojanović, Ivana and Čolić, Miodrag",
year = "2009",
abstract = "The goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain",
volume = "28",
pages = "235-242",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1182"
}
Stevanović, N. D., Jovanović, M., Jelenković, A. V., Ninković, M., Đukić, M., Stojanović, I.,& Čolić, M.. (2009). The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 28, 235-242.
https://hdl.handle.net/21.15107/rcub_farfar_1182
Stevanović ND, Jovanović M, Jelenković AV, Ninković M, Đukić M, Stojanović I, Čolić M. The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain. in General Physiology and Biophysics. 2009;28:235-242.
https://hdl.handle.net/21.15107/rcub_farfar_1182 .
Stevanović, Nana D., Jovanović, Marina, Jelenković, Ankica V., Ninković, Milica, Đukić, Mirjana, Stojanović, Ivana, Čolić, Miodrag, "The effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brain" in General Physiology and Biophysics, 28 (2009):235-242,
https://hdl.handle.net/21.15107/rcub_farfar_1182 .
