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dc.creatorStevanović, Nana D.
dc.creatorJovanović, Marina
dc.creatorJelenković, Ankica V.
dc.creatorNinković, Milica
dc.creatorĐukić, Mirjana
dc.creatorStojanović, Ivana
dc.creatorČolić, Miodrag
dc.date.accessioned2019-09-02T11:16:24Z
dc.date.available2019-09-02T11:16:24Z
dc.date.issued2009
dc.identifier.issn0231-5882
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1182
dc.description.abstractThe goal of the present study was to examine the effectiveness of a non-specific nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) to modulate the toxicity of aluminium chloride (AlCl3). Rats were killed at 3 h and at 30 days after treatments and the striatum was removed. Nitrite, superoxide, superoxide dismutase activity, malondialdehyde and reduced glutathione were determined. AlCl3 exposure promoted oxidative stress in the striatum. The biochemical changes observed in neuronal tissues show that aluminium acts as pro-oxidant, while the NOS inhibitor exerts antioxidant action in AlCl3-treated rats. We conclude that L-NAME can efficiently protect neuronal tissue from AlCl3-induced toxicity.en
dc.publisherGeneral Physiol And Biophysics, Bratislava
dc.rightsrestrictedAccess
dc.sourceGeneral Physiology and Biophysics
dc.subjectAluminiumen
dc.subjectL-NAMEen
dc.subjectNitric oxideen
dc.subjectOxidative stressen
dc.subjectStriatumen
dc.titleThe effect of inhibition of nitric oxide synthase on aluminium-induced toxicity in the rat brainen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНинковић, Милица; Ђукић, Мирјана; Јеленковић, Aнкица В.; Чолић, Миодраг; Стевановић, Нана Д.; Јовановић, Марина; Стојановић, Ивана;
dc.citation.volume28
dc.citation.spage235
dc.citation.epage242
dc.citation.other28: 235-242
dc.citation.rankM23
dc.identifier.wos000208112300034
dc.identifier.pmid19893106
dc.identifier.scopus2-s2.0-77649252601
dc.identifier.rcubconv_1485
dc.type.versionpublishedVersion


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