Приказ основних података о документу
Alpha-1-antitrypsin phenotypes in adult liver disease patients
dc.creator | Topić, Aleksandra | |
dc.creator | Alempijević, Tamara | |
dc.creator | Sokić-Milutinović, Aleksandra | |
dc.creator | Kovačević, Nada | |
dc.date.accessioned | 2019-09-02T11:16:29Z | |
dc.date.available | 2019-09-02T11:16:29Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0300-9734 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1185 | |
dc.description.abstract | Alpha-1-antitrypsin (AAT) is an important serine protease inhibitor in humans. Hereditary alpha-1-antitrypsin deficiency (AATD) affects lungs and liver. Liver disease caused by AATD in paediatric patients has been previously well documented. However, the association of liver disease with alpha-1-antitrypsin gene polymorphisms in adults is less clear. Therefore, we aimed to study AAT polymorphisms in adults with liver disease. We performed a case-control study. AAT polymorphisms were investigated by isoelectric focusing in 61 patients with liver cirrhosis and 9 patients with hepatocellular carcinoma. The control group consisted of 218 healthy blood donors. A significant deviation of observed and expected frequency of AAT phenotypes from Hardy-Weinberg equilibrium (chi-square = 34.77, df 11, P = 0.000) in the patient group was caused by a higher than expected frequency of Pi ZZ homozygotes (f = 0.0143 and f = 0.0005, respectively, P = 0.000). In addition, Pi M homozygotes were more frequent in patients than in controls (63% and 46%, respectively, P = 0.025). Our study results show that Pi ZZ homozygosity in adults could be associated with severe liver disease. Presence of Pi M homozygosity could be associated with liver disease via some mechanism different from Z allele-induced liver damage through accumulation of AAT polymers. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145011/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Upsala Journal of Medical Sciences | |
dc.subject | Adults | en |
dc.subject | alpha-1-antitrypsin | en |
dc.subject | liver disease | en |
dc.subject | phenotypes | en |
dc.title | Alpha-1-antitrypsin phenotypes in adult liver disease patients | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Aлемпијевић, Тамара; Сокић-Милутиновић, Aлександра; Топић, Aлександра; Ковачевић, Нада; | |
dc.citation.volume | 114 | |
dc.citation.issue | 4 | |
dc.citation.spage | 228 | |
dc.citation.epage | 234 | |
dc.citation.other | 114(4): 228-234 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000273527100005 | |
dc.identifier.doi | 10.3109/03009730903243472 | |
dc.identifier.pmid | 19961268 | |
dc.identifier.scopus | 2-s2.0-72449131405 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/143/1183.pdf | |
dc.type.version | publishedVersion |