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Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size

Authorized Users Only
2009
Authors
Vekić, Jelena
Zeljković, Aleksandra
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Memon, Lidija
Spasić, Slavica
Article (Published version)
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Abstract
Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P lt 0.001) and sdLDL-apoB concentrations (P lt 0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was ass...ociated with higher concentrations of both sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P lt 0.01) and sdLDL-apoB concentrations (P lt 0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.

Keywords:
Small dense LDL / Apolipoprotein B / Dyslipidemia / Menopause
Source:
Atherosclerosis, 2009, 207, 2, 496-501
Publisher:
  • Elsevier Ireland Ltd, Clare
Funding / projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.atherosclerosis.2009.06.035

ISSN: 0021-9150

PubMed: 19632678

WoS: 000273566700033

Scopus: 2-s2.0-70450248522
[ Google Scholar ]
32
28
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1186
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Memon, Lidija
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1186
AB  - Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size
VL  - 207
IS  - 2
SP  - 496
EP  - 501
DO  - 10.1016/j.atherosclerosis.2009.06.035
UR  - conv_2265
ER  - 
@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Memon, Lidija and Spasić, Slavica",
year = "2009",
abstract = "Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size",
volume = "207",
number = "2",
pages = "496-501",
doi = "10.1016/j.atherosclerosis.2009.06.035",
url = "conv_2265"
}
Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Memon, L.,& Spasić, S.. (2009). Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 207(2), 496-501.
https://doi.org/10.1016/j.atherosclerosis.2009.06.035
conv_2265
Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Memon L, Spasić S. Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis. 2009;207(2):496-501.
doi:10.1016/j.atherosclerosis.2009.06.035
conv_2265 .
Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Memon, Lidija, Spasić, Slavica, "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size" in Atherosclerosis, 207, no. 2 (2009):496-501,
https://doi.org/10.1016/j.atherosclerosis.2009.06.035 .,
conv_2265 .

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