Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size
Само за регистроване кориснике
2009
Аутори
Vekić, JelenaZeljković, Aleksandra
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Memon, Lidija
Spasić, Slavica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P lt 0.001) and sdLDL-apoB concentrations (P lt 0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was ass...ociated with higher concentrations of both sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P lt 0.01) and sdLDL-apoB concentrations (P lt 0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.
Кључне речи:
Small dense LDL / Apolipoprotein B / Dyslipidemia / MenopauseИзвор:
Atherosclerosis, 2009, 207, 2, 496-501Издавач:
- Elsevier Ireland Ltd, Clare
Финансирање / пројекти:
DOI: 10.1016/j.atherosclerosis.2009.06.035
ISSN: 0021-9150
PubMed: 19632678
WoS: 000273566700033
Scopus: 2-s2.0-70450248522
Институција/група
PharmacyTY - JOUR AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Bogavac-Stanojević, Nataša AU - Memon, Lidija AU - Spasić, Slavica PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1186 AB - Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P lt 0.001) and sdLDL-apoB concentrations (P lt 0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P lt 0.01) and sdLDL-apoB concentrations (P lt 0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination. PB - Elsevier Ireland Ltd, Clare T2 - Atherosclerosis T1 - Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size VL - 207 IS - 2 SP - 496 EP - 501 DO - 10.1016/j.atherosclerosis.2009.06.035 ER -
@article{ author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Memon, Lidija and Spasić, Slavica", year = "2009", abstract = "Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P lt 0.001) and sdLDL-apoB concentrations (P lt 0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P lt 0.01) and sdLDL-apoB concentrations (P lt 0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Atherosclerosis", title = "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size", volume = "207", number = "2", pages = "496-501", doi = "10.1016/j.atherosclerosis.2009.06.035" }
Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Memon, L.,& Spasić, S.. (2009). Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis Elsevier Ireland Ltd, Clare., 207(2), 496-501. https://doi.org/10.1016/j.atherosclerosis.2009.06.035
Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Memon L, Spasić S. Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis. 2009;207(2):496-501. doi:10.1016/j.atherosclerosis.2009.06.035 .
Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Memon, Lidija, Spasić, Slavica, "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size" in Atherosclerosis, 207, no. 2 (2009):496-501, https://doi.org/10.1016/j.atherosclerosis.2009.06.035 . .