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Relation Between 25(OH)-Vitamin D Deficiency and Markers of Bone Formation and Resorption in Haemodialysis Patients
dc.creator | Milinković, Neda | |
dc.creator | Majkić-Singh, Nada | |
dc.creator | Mirković, Duško | |
dc.creator | Beletić, Anđelo | |
dc.creator | Pejanović, Svetlana D. | |
dc.creator | Vujanić, Svetlana T. | |
dc.date.accessioned | 2019-09-02T11:16:37Z | |
dc.date.available | 2019-09-02T11:16:37Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1433-6510 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1189 | |
dc.description.abstract | Deficient serum 25-hydroxyvitamin D [25(OH)D] may contribute to the impaired bone turnover of end stage renal disease patients. In 112 hemodialysed patients we analysed the relation between 25(OH)D and bone alkaline phosphatase (BALP), beta-CrossLaps (beta-CTx) and iPTH. We analysed parameters according to the manufacturers' instructions. We found potentially significant vitamin D deficiency: 71% of patients had 25(OH)D levels below 50 nmol/L. In patients with iPTH below 150 pg/mL (n = 57), we observed significantly low 25(OH) (p lt 0.01). In addition, patients with iPTH above 300 pg/mL had higher BALP levels (p lt 0.05). There were negative correlations between serum 25(OH)D and both BALP and iPTH (r = -0.225, p lt 0.05 and r = -0.331, p lt 0.05). Beta-CTx levels were significantly higher in patients who did not receive vitamin D supplementation (p lt 0.01). In addition, reduced BALP and iPTH levels indicate decreased bone turnover. Recorded data could signify that vitamin D deficiency may contribute to the impaired bone metabolism of hemodialysis patients. (Clin. Lab. 2009;55:333-339) | en |
dc.publisher | Clin Lab Publ, Heidelberg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145010/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Laboratory | |
dc.subject | Vitamin D | en |
dc.subject | bone alkaline phosphatase | en |
dc.subject | beta-CrossLaps | en |
dc.subject | parathyroid hormone | en |
dc.subject | hemodialysis | en |
dc.subject | bone metabolism | en |
dc.title | Relation Between 25(OH)-Vitamin D Deficiency and Markers of Bone Formation and Resorption in Haemodialysis Patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мајкић-Сингх, Нада; Пејановић, Светлана Д.; Белетић, Aнђело; Милинковић, Неда; Вујанић, Светлана Т.; Мирковић, Душко; | |
dc.citation.volume | 55 | |
dc.citation.issue | 9-10 | |
dc.citation.spage | 333 | |
dc.citation.epage | 339 | |
dc.citation.other | 55(9-10): 333-339 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000273176900001 | |
dc.identifier.pmid | 20099569 | |
dc.identifier.scopus | 2-s2.0-75749088406 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1189 | |
dc.type.version | publishedVersion |
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