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Should we routinely measure low-density and high-density lipoprotein subclasses?

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Authors
Rizzo, Manfredi
Berneis, Kaspar
Zeljković, Aleksandra
Vekić, Jelena
Article (Published version)
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Abstract
Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) plasma populations are composed of heterogeneous subfractions that are different in size, density and protein/lipid content. There is increasing evidence that small, dense LDL particles are strongly associated with higher cardiovascular disease risk. Similarly, several studies have investigated whether smaller HDL particles are more protective than their larger counterparts and more recent findings suggest that small, dense HDL has significantly higher atheroprotective activity than larger L HDL. Yet, certain impairments of the protein/lipid content in small, dense HDL may decrease its antiatherogenic capacity or even induce pro-atherogenic properties. Therefore, it seems that the small, dense phenomenon applies to both LDL and HDL particles. Measurement of LDL and HDL cholesterol concentrations has proven clinical utility, while the usefulness of LDL and HDL subclasses determination in clinical practice offers grounds fo...r further exploration. However, LDL and HDL particles characterisation requires either special equipment or a lengthy analytical time and is, therefore, still unsuitable for general clinical use. It remains to be established whether lipoprotein subclasses should be analyzed in routine practice, although their assessment in high-risk subjects could be recommended. (Clin. Lab. 2009;55:421-429)

Keywords:
LDL / HDL / lipoproteins / subclasses / cardiovascular risk
Source:
Clinical Laboratory, 2009, 55, 11-12, 421-429
Publisher:
  • Clin Lab Publ, Heidelberg

ISSN: 1433-6510

PubMed: 20225664

WoS: 000274525600002

Scopus: 2-s2.0-77749316174
[ Google Scholar ]
38
31
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1190
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1190
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Rizzo, Manfredi
AU  - Berneis, Kaspar
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1190
AB  - Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) plasma populations are composed of heterogeneous subfractions that are different in size, density and protein/lipid content. There is increasing evidence that small, dense LDL particles are strongly associated with higher cardiovascular disease risk. Similarly, several studies have investigated whether smaller HDL particles are more protective than their larger counterparts and more recent findings suggest that small, dense HDL has significantly higher atheroprotective activity than larger L HDL. Yet, certain impairments of the protein/lipid content in small, dense HDL may decrease its antiatherogenic capacity or even induce pro-atherogenic properties. Therefore, it seems that the small, dense phenomenon applies to both LDL and HDL particles. Measurement of LDL and HDL cholesterol concentrations has proven clinical utility, while the usefulness of LDL and HDL subclasses determination in clinical practice offers grounds for further exploration. However, LDL and HDL particles characterisation requires either special equipment or a lengthy analytical time and is, therefore, still unsuitable for general clinical use. It remains to be established whether lipoprotein subclasses should be analyzed in routine practice, although their assessment in high-risk subjects could be recommended. (Clin. Lab. 2009;55:421-429)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Should we routinely measure low-density and high-density lipoprotein subclasses?
VL  - 55
IS  - 11-12
SP  - 421
EP  - 429
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1190
ER  - 
@article{
author = "Rizzo, Manfredi and Berneis, Kaspar and Zeljković, Aleksandra and Vekić, Jelena",
year = "2009",
abstract = "Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) plasma populations are composed of heterogeneous subfractions that are different in size, density and protein/lipid content. There is increasing evidence that small, dense LDL particles are strongly associated with higher cardiovascular disease risk. Similarly, several studies have investigated whether smaller HDL particles are more protective than their larger counterparts and more recent findings suggest that small, dense HDL has significantly higher atheroprotective activity than larger L HDL. Yet, certain impairments of the protein/lipid content in small, dense HDL may decrease its antiatherogenic capacity or even induce pro-atherogenic properties. Therefore, it seems that the small, dense phenomenon applies to both LDL and HDL particles. Measurement of LDL and HDL cholesterol concentrations has proven clinical utility, while the usefulness of LDL and HDL subclasses determination in clinical practice offers grounds for further exploration. However, LDL and HDL particles characterisation requires either special equipment or a lengthy analytical time and is, therefore, still unsuitable for general clinical use. It remains to be established whether lipoprotein subclasses should be analyzed in routine practice, although their assessment in high-risk subjects could be recommended. (Clin. Lab. 2009;55:421-429)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Should we routinely measure low-density and high-density lipoprotein subclasses?",
volume = "55",
number = "11-12",
pages = "421-429",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1190"
}
Rizzo, M., Berneis, K., Zeljković, A.,& Vekić, J.. (2009). Should we routinely measure low-density and high-density lipoprotein subclasses?. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 55(11-12), 421-429.
https://hdl.handle.net/21.15107/rcub_farfar_1190
Rizzo M, Berneis K, Zeljković A, Vekić J. Should we routinely measure low-density and high-density lipoprotein subclasses?. in Clinical Laboratory. 2009;55(11-12):421-429.
https://hdl.handle.net/21.15107/rcub_farfar_1190 .
Rizzo, Manfredi, Berneis, Kaspar, Zeljković, Aleksandra, Vekić, Jelena, "Should we routinely measure low-density and high-density lipoprotein subclasses?" in Clinical Laboratory, 55, no. 11-12 (2009):421-429,
https://hdl.handle.net/21.15107/rcub_farfar_1190 .

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