Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release ...profile.
Keywords:
Sustained release dosage form / Mixture experimental design / HPMC/carbomer matrices / In vitro tests / Dissolution
Source:
Archives of Pharmacal Research, 2009, 32, 12, 1767-1774
TY - JOUR
AU - Petrović, Aleksandra
AU - Cvetković, Nebojša
AU - Ibrić, Svetlana
AU - Trajković, Svetlana
AU - Đurić, Zorica
AU - Popadić, Dragica
AU - Popović, Radmila
PY - 2009
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1191
AB - Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
PB - Pharmaceutical Soc Korea, Seoul
T2 - Archives of Pharmacal Research
T1 - Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose
VL - 32
IS - 12
SP - 1767
EP - 1774
DO - 10.1007/s12272-009-2215-9
ER -
@article{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Đurić, Zorica and Popadić, Dragica and Popović, Radmila",
year = "2009",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1191",
abstract = "Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose",
volume = "32",
number = "12",
pages = "1767-1774",
doi = "10.1007/s12272-009-2215-9"
}
Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Đurić, Z., Popadić, D.,& Popović, R. (2009). Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose.
Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(12), 1767-1774.
https://doi.org/10.1007/s12272-009-2215-9
Petrović A, Cvetković N, Ibrić S, Trajković S, Đurić Z, Popadić D, Popović R. Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. Archives of Pharmacal Research. 2009;32(12):1767-1774
Petrović Aleksandra, Cvetković Nebojša, Ibrić Svetlana, Trajković Svetlana, Đurić Zorica, Popadić Dragica, Popović Radmila, "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose" Archives of Pharmacal Research, 32, no. 12 (2009):1767-1774,
https://doi.org/10.1007/s12272-009-2215-9 .
