FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices

Authorized Users Only
2009
Authors
Petrović, Jelena
Jocković, Jelena
Ibrić, Svetlana
Đurić, Zorica
Article (Published version)
Metadata
Show full item record
Abstract
Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes ...in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.

Keywords:
controlled release / diffusion / mathematical modelling / polyethylene oxide (PEO) matrix / swelling
Source:
Journal of Pharmacy and Pharmacology, 2009, 61, 11, 1449-1456
Publisher:
  • Wiley-Blackwell Publishing, Inc, Malden
Funding / projects:
  • Razvoj i primena in vitro i in silico metoda u biofarmaceutskoj karakterizaciji lekova BSK grupe 2 i 3 (RS-23015)

DOI: 10.1211/jpp/61.11.0003

ISSN: 0022-3573

PubMed: 19903369

WoS: 000281136600003

Scopus: 2-s2.0-75749118969
[ Google Scholar ]
9
7
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1193
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Petrović, Jelena
AU  - Jocković, Jelena
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1193
AB  - Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.
PB  - Wiley-Blackwell Publishing, Inc, Malden
T2  - Journal of Pharmacy and Pharmacology
T1  - Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices
VL  - 61
IS  - 11
SP  - 1449
EP  - 1456
DO  - 10.1211/jpp/61.11.0003
ER  - 
@article{
author = "Petrović, Jelena and Jocković, Jelena and Ibrić, Svetlana and Đurić, Zorica",
year = "2009",
abstract = "Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Journal of Pharmacy and Pharmacology",
title = "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices",
volume = "61",
number = "11",
pages = "1449-1456",
doi = "10.1211/jpp/61.11.0003"
}
Petrović, J., Jocković, J., Ibrić, S.,& Đurić, Z.. (2009). Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology
Wiley-Blackwell Publishing, Inc, Malden., 61(11), 1449-1456.
https://doi.org/10.1211/jpp/61.11.0003
Petrović J, Jocković J, Ibrić S, Đurić Z. Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology. 2009;61(11):1449-1456.
doi:10.1211/jpp/61.11.0003 .
Petrović, Jelena, Jocković, Jelena, Ibrić, Svetlana, Đurić, Zorica, "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices" in Journal of Pharmacy and Pharmacology, 61, no. 11 (2009):1449-1456,
https://doi.org/10.1211/jpp/61.11.0003 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB