Synthesis and Anti-inflammatory Activity of New alpha-Oxyalcanoyl Esters of Fluocinolone Acetonide
Abstract
In this study it was described synthesis of new C-21 esters of fluocinolone acetonide with alpha-alkoxyalcanoic and alpha-aryloxyalkanoic acids. Esterification with these branched oxyacids has to improve benefit-risk ratio. All synthesized compound were shown some topical anti-inflammatory activity.
Source:
Joint Meeting on Medical Chemistry, 2009, 41-Publisher:
- Medimond S R L, 40128 Bologna