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dc.creatorJovičić, Snežana
dc.creatorIgnjatović, Svetlana
dc.creatorDajak, Marijana
dc.creatorKangrga, Ranka
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:16:49Z
dc.date.available2019-09-02T11:16:49Z
dc.date.issued2009
dc.identifier.issn1433-6510
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1198
dc.description.abstractBackground: High-sensitivity C-reactive protein (hsCRP) has been recognized as an independent marker of cardiovascular risk. Since atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia. Materials and Methods: In 242 healthy volunteers, total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), nonHDL-C, triglycerides (TG) and hsCRP were measured using Olympus AU2700. Apolipoprotein A-1 (apoA1), apolipoprotein B (apo B), lipoprotein (a) (Lp(a)), haptoglobin, alpha(1)-acid glycoprotein (A1AGP), C3 and C4 complement components were determined on Architect c8000, and serum amyloid A (SAA) and fibrinogen on BN II nephelometer and ACL 7000, respectively. Results: Significant (P lt 0.05) partial Pearson's correlation coefficients were found between hsCRP and TC (r = 0.172), nonHDL-C (r = 0.182), LDL-C (r = 0.154), apoB (r = 0.167), fibrinogen (r = 0.411), SAA (r = 0.493), A1AGP (r = 0.462), haptoglobin (r = 0.310), C3 (r = 0.349) and C4 (r = 0.371). In multiple regression analysis, BMI, SAA, A1AGP, fibrinogen and nonHDL-C showed independent correlation with hsCRP. Multinomial logistic regression analysis demonstrated that BMI, nonHDL, fibrinogen and SAA were strong predictors of hsCRP concentration. Odds ratios for intermediate and high risk categories compared with the low risk category were 1.177 (1.033-1.341) and 1.289 (1.091-1.523), 1.515 (1.021-2.249) and 2.062 (1.246-3.411), 2.241 (1.268-3.959) and 7.123 (3.259-15.568), and 1.387 (1.179-1.632) and 1.691 (1.397-2.047), for BMI, nonHDL-C, fibrinogen and SAA, respectively. Conclusion: The prediction of risk for future cardiac events based on hsCRP concentration, which is the recommended parameter for improving cardiovascular risk stratification, might be complemented with the information about BMI, nonHDL-C, fibrinogen and SAA. (Clin. Lab. 2009;55:411-419)en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145010/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjecthsCRPen
dc.subjectinflammationen
dc.subjectdyslipidemiaen
dc.subjectcardiovascular risk assessmenten
dc.subjectFramingham risk scoreen
dc.titleAssociation of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Preventionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМајкић-Сингх, Нада; Дајак, Маријана; Кангрга, Ранка; Игњатовић, Светлана; Јовичић, Снежана;
dc.citation.volume55
dc.citation.issue11-12
dc.citation.spage411
dc.citation.epage419
dc.citation.other55(11-12): 411-419
dc.citation.rankM23
dc.identifier.wos000274525600001
dc.identifier.pmid20225663
dc.identifier.rcubconv_2270
dc.type.versionpublishedVersion


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