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dc.creatorVujić, Zorica
dc.creatorRadulović, Dušanka
dc.creatorŽivanović, Ljiljana
dc.date.accessioned2019-09-02T10:48:56Z
dc.date.available2019-09-02T10:48:56Z
dc.date.issued1995
dc.identifier.issn0014-827X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/119
dc.description.abstractA sensitive spectrophotometric method for the determination of metoprolol tartrate in tablets and ampoules is presented. Using spectrophotometric measurements, it was found that metoprolol tartrate and benzyl orange form a chloroform soluble ion-pair complex with an absorption maximum at 401 nm. The composition of the ion-pair complex was determined by applying Job's method to equimolar solutions of metoprolol tartrate: benzyl orange (1:2); molar absorptivity 7.39 x 103 mol-1 cm-1. Extraction of the ion-pair complex in chloroform was accomplished easily at a Britton-Robinson's buffered optimum pH = 5.2, μ = 0.1 mol/dm3. The relative stability constant, calculated according to the method of Sommer and Job's non-equimolar solutions, was log K = 9.72 (avg. value). Beer's law was obeyed up to 3.42 μg/ml of metoprolol tartrate (the detection limit was also 3.42 μg/ml). The precision of the method was checked at three different concentrations. The RSD (n = 7) varied from 0.51 to 2.03%. Reproducibility was examined by analysing Lopresor® tablets and ampoules. Recoveries varied from 99-101%. The reported method, applied to the assay of metoprolol tartrate in tablets and ampoules, gives precise and reproducible results.en
dc.rightsrestrictedAccess
dc.sourceFarmaco
dc.titleSpectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage formsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВујић, Зорица; Живановић, Љиљана; Радуловић, Душанка;
dc.citation.volume50
dc.citation.issue4
dc.citation.spage281
dc.citation.epage284
dc.citation.other50(4): 281-284
dc.identifier.scopus2-s2.0-0028990058
dc.identifier.rcubconv_5438
dc.type.versionpublishedVersion


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