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Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats

Authorized Users Only
2009
Authors
Zdunić, Gordana
Gođevac, Dejan
Milenković, Marina
Vučićević, Dragana
Šavikin, Katarina
Menković, Nebojša
Petrović, Silvana
Article (Published version)
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Abstract
Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectiv...ely). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright

Keywords:
Hypericum perforatum L. / Oleum Hyperici / quercetin / I3,II8-biapigenin / anti-inflammatory activity / gastroprotective activity
Source:
Phytotherapy Research, 2009, 23, 11, 1559-1564
Publisher:
  • John Wiley & Sons Ltd, Chichester
Projects:
  • Biljni proizvodi u preventivi i terapiji nezaraznih hroničnih oboljenja kod ljudi (RS-20035)

DOI: 10.1002/ptr.2809

ISSN: 0951-418X

PubMed: 19367676

WoS: 000271782500010

Scopus: 2-s2.0-70350439495
[ Google Scholar ]
39
33
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1206
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Milenković, Marina
AU  - Vučićević, Dragana
AU  - Šavikin, Katarina
AU  - Menković, Nebojša
AU  - Petrović, Silvana
PY  - 2009
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1206
AB  - Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats
VL  - 23
IS  - 11
SP  - 1559
EP  - 1564
DO  - 10.1002/ptr.2809
ER  - 
@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Vučićević, Dragana and Šavikin, Katarina and Menković, Nebojša and Petrović, Silvana",
year = "2009",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1206",
abstract = "Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats",
volume = "23",
number = "11",
pages = "1559-1564",
doi = "10.1002/ptr.2809"
}
Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, Petrović S. Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats. Phytotherapy Research. 2009;23(11):1559-1564
Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N.,& Petrović, S. (2009). Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats.
Phytotherapy ResearchJohn Wiley & Sons Ltd, Chichester., 23(11), 1559-1564.
https://doi.org/10.1002/ptr.2809
Zdunić Gordana, Gođevac Dejan, Milenković Marina, Vučićević Dragana, Šavikin Katarina, Menković Nebojša, Petrović Silvana, "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats" 23, no. 11 (2009):1559-1564,
https://doi.org/10.1002/ptr.2809 .

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