Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats
Само за регистроване кориснике
2009
Аутори
Zdunić, GordanaGođevac, Dejan
Milenković, Marina
Vučićević, Dragana
Šavikin, Katarina
Menković, Nebojša
Petrović, Silvana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectiv...ely). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright
Кључне речи:
Hypericum perforatum L. / Oleum Hyperici / quercetin / I3,II8-biapigenin / anti-inflammatory activity / gastroprotective activityИзвор:
Phytotherapy Research, 2009, 23, 11, 1559-1564Издавач:
- John Wiley & Sons Ltd, Chichester
Финансирање / пројекти:
DOI: 10.1002/ptr.2809
ISSN: 0951-418X
PubMed: 19367676
WoS: 000271782500010
Scopus: 2-s2.0-70350439495
Институција/група
PharmacyTY - JOUR AU - Zdunić, Gordana AU - Gođevac, Dejan AU - Milenković, Marina AU - Vučićević, Dragana AU - Šavikin, Katarina AU - Menković, Nebojša AU - Petrović, Silvana PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1206 AB - Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright PB - John Wiley & Sons Ltd, Chichester T2 - Phytotherapy Research T1 - Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats VL - 23 IS - 11 SP - 1559 EP - 1564 DO - 10.1002/ptr.2809 ER -
@article{ author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Vučićević, Dragana and Šavikin, Katarina and Menković, Nebojša and Petrović, Silvana", year = "2009", abstract = "Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyright", publisher = "John Wiley & Sons Ltd, Chichester", journal = "Phytotherapy Research", title = "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats", volume = "23", number = "11", pages = "1559-1564", doi = "10.1002/ptr.2809" }
Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N.,& Petrović, S.. (2009). Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats. in Phytotherapy Research John Wiley & Sons Ltd, Chichester., 23(11), 1559-1564. https://doi.org/10.1002/ptr.2809
Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, Petrović S. Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats. in Phytotherapy Research. 2009;23(11):1559-1564. doi:10.1002/ptr.2809 .
Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Vučićević, Dragana, Šavikin, Katarina, Menković, Nebojša, Petrović, Silvana, "Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats" in Phytotherapy Research, 23, no. 11 (2009):1559-1564, https://doi.org/10.1002/ptr.2809 . .