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dc.creatorZdunić, Gordana
dc.creatorGođevac, Dejan
dc.creatorMilenković, Marina
dc.creatorVučićević, Dragana
dc.creatorŠavikin, Katarina
dc.creatorMenković, Nebojša
dc.creatorPetrović, Silvana
dc.date.accessioned2019-09-02T11:16:59Z
dc.date.available2019-09-02T11:16:59Z
dc.date.issued2009
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1206
dc.description.abstractOil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyrighten
dc.publisherJohn Wiley & Sons Ltd, Chichester
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/20035/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectHypericum perforatum L.en
dc.subjectOleum Hypericien
dc.subjectquercetinen
dc.subjectI3,II8-biapigeninen
dc.subjectanti-inflammatory activityen
dc.subjectgastroprotective activityen
dc.titleEvaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМенковић, Небојша; Здунић, Гордана; Шавикин, Катарина; Петровић, Силвана; Миленковић, Марина; Гођевац, Дејан; Вучићевић, Драгана;
dc.citation.volume23
dc.citation.issue11
dc.citation.spage1559
dc.citation.epage1564
dc.citation.other23(11): 1559-1564
dc.citation.rankM22
dc.identifier.wos000271782500010
dc.identifier.doi10.1002/ptr.2809
dc.identifier.pmid19367676
dc.identifier.scopus2-s2.0-70350439495
dc.identifier.rcubconv_2252
dc.type.versionpublishedVersion


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