Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentr...ations improves the prediction of CAD based on existing biomarkers.
TY - JOUR
AU - Jelić-Ivanović, Zorana
AU - Bujisić, Nada
AU - Spasić, Slavica
AU - Bogavac-Stanojević, Nataša
AU - Spasojević-Kalimanovska, Vesna
AU - Kotur-Stevuljević, Jelena
PY - 2009
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1210
AB - Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Clinical Biochemistry
T1 - Circulating sTWEAK improves the prediction of coronary artery disease
VL - 42
IS - 13-14
SP - 1381
EP - 1386
DO - 10.1016/j.clinbiochem.2009.06.001
ER -
@article{
author = "Jelić-Ivanović, Zorana and Bujisić, Nada and Spasić, Slavica and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena",
year = "2009",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1210",
abstract = "Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Circulating sTWEAK improves the prediction of coronary artery disease",
volume = "42",
number = "13-14",
pages = "1381-1386",
doi = "10.1016/j.clinbiochem.2009.06.001"
}
Jelić-Ivanović Z, Bujisić N, Spasić S, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Circulating sTWEAK improves the prediction of coronary artery disease. Clinical Biochemistry. 2009;42(13-14):1381-1386
