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dc.creatorJelić-Ivanović, Zorana
dc.creatorBujisić, Nada
dc.creatorSpasić, Slavica
dc.creatorBogavac-Stanojević, Nataša
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKotur-Stevuljević, Jelena
dc.date.accessioned2019-09-02T11:17:06Z
dc.date.available2019-09-02T11:17:06Z
dc.date.issued2009
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1210
dc.description.abstractObjectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectAtherosclerosisen
dc.subjectRisk factorsen
dc.subjectCoronary artery diseaseen
dc.subjectROC curve analysisen
dc.subjectBiomarkersen
dc.subjectsTWEAKen
dc.titleCirculating sTWEAK improves the prediction of coronary artery diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБујисић, Нада; Богавац-Станојевић, Наташа; Спасојевић-Калимановска, Весна; Јелић-Ивановић, Зорана; Котур-Стевуљевић, Јелена; Спасић, Славица;
dc.citation.volume42
dc.citation.issue13-14
dc.citation.spage1381
dc.citation.epage1386
dc.citation.other42(13-14): 1381-1386
dc.citation.rankM21
dc.identifier.wos000272261800008
dc.identifier.doi10.1016/j.clinbiochem.2009.06.001
dc.identifier.pmid19505454
dc.identifier.scopus2-s2.0-69249205389
dc.identifier.rcubconv_2256
dc.type.versionpublishedVersion


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