FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?

Thumbnail
2009
1210.pdf (693.3Kb)
Authors
Bajić, Vladan
Potparević, Biljana
Živković, Lada
Bonda, David J.
Siedlak, Sandra L.
Casadesus, Gemma
Lee, Hyoung-Gon
Smith, Mark A.
Article (Published version)
Metadata
Show full item record
Abstract
Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression... of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.

Source:
Medical Hypotheses, 2009, 73, 6, 917-920
Publisher:
  • Churchill Livingstone, Edinburgh
Projects:
  • Evaluacija dejstva hormona i citostatika prmenom citogenetičkih analiza i Komet testa (RS-143018)

DOI: 10.1016/j.mehy.2009.06.046

ISSN: 0306-9877

PubMed: 19647374

WoS: 000272923000011

Scopus: 2-s2.0-70450248506
[ Google Scholar ]
21
21
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1212
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB