Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine
Само за регистроване кориснике
2009
Аутори
Mitić, DraganaMilenković, Marina
Milosavljević, Slobodan
Gođevac, Dejan
Miodragović, Zoran M.
Anđelković, Katarina
Miodragović, Djenana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and H-1, C-13 and N-15 NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans.
Кључне речи:
Antimicrobial activity / Co(II), Zn(II), Cd(II) complexes / N-Benzyloxycarbonyl-S-phenylalanine / 2D NMRИзвор:
European Journal of Medicinal Chemistry, 2009, 44, 4, 1537-1544Издавач:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Финансирање / пројекти:
- Синтеза, анализа и активност нових органских полидентатних лиганада и њихових комплекса са d-металима (RS-142062)
DOI: 10.1016/j.ejmech.2008.07.017
ISSN: 0223-5234
PubMed: 18760509
WoS: 000264920000018
Scopus: 2-s2.0-61549109905
Институција/група
PharmacyTY - JOUR AU - Mitić, Dragana AU - Milenković, Marina AU - Milosavljević, Slobodan AU - Gođevac, Dejan AU - Miodragović, Zoran M. AU - Anđelković, Katarina AU - Miodragović, Djenana PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1222 AB - In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and H-1, C-13 and N-15 NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine VL - 44 IS - 4 SP - 1537 EP - 1544 DO - 10.1016/j.ejmech.2008.07.017 ER -
@article{ author = "Mitić, Dragana and Milenković, Marina and Milosavljević, Slobodan and Gođevac, Dejan and Miodragović, Zoran M. and Anđelković, Katarina and Miodragović, Djenana", year = "2009", abstract = "In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and H-1, C-13 and N-15 NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine", volume = "44", number = "4", pages = "1537-1544", doi = "10.1016/j.ejmech.2008.07.017" }
Mitić, D., Milenković, M., Milosavljević, S., Gođevac, D., Miodragović, Z. M., Anđelković, K.,& Miodragović, D.. (2009). Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1537-1544. https://doi.org/10.1016/j.ejmech.2008.07.017
Mitić D, Milenković M, Milosavljević S, Gođevac D, Miodragović ZM, Anđelković K, Miodragović D. Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry. 2009;44(4):1537-1544. doi:10.1016/j.ejmech.2008.07.017 .
Mitić, Dragana, Milenković, Marina, Milosavljević, Slobodan, Gođevac, Dejan, Miodragović, Zoran M., Anđelković, Katarina, Miodragović, Djenana, "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1537-1544, https://doi.org/10.1016/j.ejmech.2008.07.017 . .