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Atherogenic dyslipidemia and oxidative stress: a new look

Authorized Users Only
2009
Authors
Rizzo, Manfredi
Kotur-Stevuljević, Jelena
Berneis, Kaspar
Spinas, Giatgen
Rini, Giovam Battista
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Article (Published version)
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Abstract
Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
Source:
Transplant International, 2009, 153, 5, 217-223
Publisher:
  • Elsevier Science Inc, New York
Projects:
  • Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-145036)

DOI: 10.1016/j.trsl.2009.01.008

ISSN: 1931-5244

PubMed: 19375682

WoS: 000265756600002

Scopus: 2-s2.0-64349105661
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1228
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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