Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
TY - JOUR
AU - Rizzo, Manfredi
AU - Kotur-Stevuljević, Jelena
AU - Berneis, Kaspar
AU - Spinas, Giatgen
AU - Rini, Giovam Battista
AU - Jelić-Ivanović, Zorana
AU - Spasojević-Kalimanovska, Vesna
AU - Vekić, Jelena
PY - 2009
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1228
AB - Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
PB - Elsevier Science Inc, New York
T2 - Transplant International
T1 - Atherogenic dyslipidemia and oxidative stress: a new look
VL - 153
IS - 5
SP - 217
EP - 223
DO - 10.1016/j.trsl.2009.01.008
ER -
@article{
author = "Rizzo, Manfredi and Kotur-Stevuljević, Jelena and Berneis, Kaspar and Spinas, Giatgen and Rini, Giovam Battista and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Vekić, Jelena",
year = "2009",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1228",
abstract = "Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)",
publisher = "Elsevier Science Inc, New York",
journal = "Transplant International",
title = "Atherogenic dyslipidemia and oxidative stress: a new look",
volume = "153",
number = "5",
pages = "217-223",
doi = "10.1016/j.trsl.2009.01.008"
}
Rizzo, M., Kotur-Stevuljević, J., Berneis, K., Spinas, G., Rini, G. B., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Vekić, J. (2009). Atherogenic dyslipidemia and oxidative stress: a new look.
Transplant International
Elsevier Science Inc, New York., 153(5), 217-223.
https://doi.org/10.1016/j.trsl.2009.01.008
Rizzo M, Kotur-Stevuljević J, Berneis K, Spinas G, Rini GB, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Vekić J. Atherogenic dyslipidemia and oxidative stress: a new look. Transplant International. 2009;153(5):217-223
