Protolytic equilibria of midazolam in the pH range 0-12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I = 0.1 mol l-1 (NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated.
TY - JOUR
AU - Pfendt, Lidija
AU - Janjić, T.J
AU - Popović, Gordana
PY - 1995
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/123
AB - Protolytic equilibria of midazolam in the pH range 0-12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I = 0.1 mol l-1 (NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated.
T2 - The Analyst
T1 - Study of protolytic, hydrolytic and solubility equilibria of midazolam
VL - 120
IS - 8
SP - 2145
EP - 2151
DO - 10.1039/AN9952002145
ER -
@article{
author = "Pfendt, Lidija and Janjić, T.J and Popović, Gordana",
year = "1995",
abstract = "Protolytic equilibria of midazolam in the pH range 0-12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I = 0.1 mol l-1 (NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated.",
journal = "The Analyst",
title = "Study of protolytic, hydrolytic and solubility equilibria of midazolam",
volume = "120",
number = "8",
pages = "2145-2151",
doi = "10.1039/AN9952002145"
}
Pfendt, L., Janjić, T.J,& Popović, G.. (1995). Study of protolytic, hydrolytic and solubility equilibria of midazolam. in The Analyst, 120(8), 2145-2151.
https://doi.org/10.1039/AN9952002145
Pfendt L, Janjić T, Popović G. Study of protolytic, hydrolytic and solubility equilibria of midazolam. in The Analyst. 1995;120(8):2145-2151.
doi:10.1039/AN9952002145 .
Pfendt, Lidija, Janjić, T.J, Popović, Gordana, "Study of protolytic, hydrolytic and solubility equilibria of midazolam" in The Analyst, 120, no. 8 (1995):2145-2151,
https://doi.org/10.1039/AN9952002145 . .
