Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller ...PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.
TY - JOUR
AU - Dragičević-Curić, Nina
AU - Winter, Sven
AU - Stupar, Mirjana
AU - Milić, Jela
AU - Krajišnik, Danina
AU - Gitter, Burkhard
AU - Fahr, Alfred
PY - 2009
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1231
AB - Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.
PB - Elsevier Science BV, Amsterdam
T2 - International Journal of Pharmaceutics
T1 - Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration
VL - 373
IS - 1-2
SP - 77
EP - 84
DO - 10.1016/j.ijpharm.2009.02.010
ER -
@article{
author = "Dragičević-Curić, Nina and Winter, Sven and Stupar, Mirjana and Milić, Jela and Krajišnik, Danina and Gitter, Burkhard and Fahr, Alfred",
year = "2009",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1231",
abstract = "Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration",
volume = "373",
number = "1-2",
pages = "77-84",
doi = "10.1016/j.ijpharm.2009.02.010"
}
Dragičević-Curić, N., Winter, S., Stupar, M., Milić, J., Krajišnik, D., Gitter, B.,& Fahr, A. (2009). Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration.
International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 373(1-2), 77-84.
https://doi.org/10.1016/j.ijpharm.2009.02.010
Dragičević-Curić N, Winter S, Stupar M, Milić J, Krajišnik D, Gitter B, Fahr A. Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration. International Journal of Pharmaceutics. 2009;373(1-2):77-84
Dragičević-Curić Nina, Winter Sven, Stupar Mirjana, Milić Jela, Krajišnik Danina, Gitter Burkhard, Fahr Alfred, "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration" International Journal of Pharmaceutics, 373, no. 1-2 (2009):77-84,
https://doi.org/10.1016/j.ijpharm.2009.02.010 .
