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dc.creatorDragičević-Curić, Nina
dc.creatorWinter, Sven
dc.creatorStupar, Mirjana
dc.creatorMilić, Jela
dc.creatorKrajišnik, Danina
dc.creatorGitter, Burkhard
dc.creatorFahr, Alfred
dc.date.accessioned2019-09-02T11:17:38Z
dc.date.available2019-09-02T11:17:38Z
dc.date.issued2009
dc.identifier.issn0378-5173
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1231
dc.description.abstractTemoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectTemoporfinen
dc.subjectLiposomeen
dc.subjectLiposomal hydrogelen
dc.subjectCarbomeren
dc.subjectSkin penetrationen
dc.subjectViscoelastic propertiesen
dc.titleTemoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetrationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКрајишник, Данина; Wинтер, Свен; Гиттер, Буркхард; Драгичевић-Цурић, Нина; Ступар, Мирјана; Милић, Јела; Фахр, Aлфред;
dc.citation.volume373
dc.citation.issue1-2
dc.citation.spage77
dc.citation.epage84
dc.citation.other373(1-2): 77-84
dc.citation.rankM22
dc.identifier.wos000266307100011
dc.identifier.doi10.1016/j.ijpharm.2009.02.010
dc.identifier.pmid19429291
dc.identifier.scopus2-s2.0-67349134179
dc.type.versionpublishedVersion


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Приказ основних података о документу