Study of protolytic, hydrolytic and solubility equilibria of midazolam

dc.creator	Pfendt, Lidija
dc.creator	Janjić, T.J
dc.creator	Popović, Gordana
dc.date.accessioned	2019-09-02T10:49:04Z
dc.date.available	2019-09-02T10:49:04Z
dc.date.issued	1995
dc.identifier.issn	0003-2654
dc.identifier.uri	https://farfar.pharmacy.bg.ac.rs/handle/123456789/123
dc.description.abstract	Protolytic equilibria of midazolam in the pH range 0-12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I = 0.1 mol l-1 (NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated.	en
dc.rights	restrictedAccess
dc.source	The Analyst
dc.subject	Heterogeneous equilibria	en
dc.subject	Hydrolysis	en
dc.subject	Midazolam	en
dc.subject	Protolytic equilibria	en
dc.subject	Single- and two-phase buffer	en
dc.title	Study of protolytic, hydrolytic and solubility equilibria of midazolam	en
dc.type	article
dc.rights.license	ARR
dcterms.abstract	Пфендт, Лидија; Јањић, Т.Ј; Поповић, Гордана;
dc.citation.volume	120
dc.citation.issue	8
dc.citation.spage	2145
dc.citation.epage	2151
dc.citation.other	120(8): 2145-2151
dc.identifier.doi	10.1039/AN9952002145
dc.identifier.scopus	2-s2.0-0029149896
dc.type.version	publishedVersion