Show simple item record

dc.creatorVučićević, Katarina
dc.creatorPopović, Gordana
dc.creatorNikolić, Katarina
dc.creatorVovk, Irena
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:17:51Z
dc.date.available2019-09-02T11:17:51Z
dc.date.issued2009
dc.identifier.issn1082-6076
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1241
dc.description.abstractIn order to improve the chromatographic resolution (Rs) with a good analysis time, experimental designs were applied for multivariate optimization of the experimental conditions of an isocratic reversed phase high performance liquid chromatographic (RP-HPLC) method used for the simultaneous determination of seven 2-arylimidazoline derivatives, acting as vasoconstrictors and antihypertensives. Optimal conditions for the separation of the seven 2-arylimidazolines were obtained using a mixture of acetonitrile-triethylamine phosphate buffer (pH 4.0; 25mM) (30:70, v/v) as mobile phase at 25C. Here the 23 full factorial experimental design was employed to optimize RP-HPLC separation of the 2-arylimidazolines. The suggested RP-HPLC method is applicable for routine analysis of the 2-arylimidazoline derivatives under the same chromatographic conditions, which can shorten the time and the costs of the analysis as well. Detailed description of the method development and optimization given in this paper will enhance the reproducibility of the established experimental conditions and simplify the process of some future methods developments.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectAlpha agonisten
dc.subjectExperimental designen
dc.subjectOptimization of HPLC methoden
dc.titleAn Experimental Design Approach to Selecting the Optimum HPLC Conditions for the Determination of 2-Arylimidazoline Derivativesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВовк, Ирена; Поповић, Гордана; Николић, Катарина; Вучићевић, Катарина; Aгбаба, Даница;
dc.citation.volume32
dc.citation.issue5
dc.citation.spage656
dc.citation.epage667
dc.citation.other32(5): 656-667
dc.citation.rankM23
dc.identifier.wos000262908400004
dc.identifier.doi10.1080/10826070802711113
dc.identifier.scopus2-s2.0-61749097206
dc.identifier.rcubconv_2108
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record