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Artificial neural networks in analysis of indinavir and its degradation products retention

Authorized Users Only
2009
Authors
Jančić-Stojanović, Biljana
Ivanović, D.
Malenović, Anđelija
Medenica, Mirjana
Article (Published version)
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Abstract
Artificial neural networks (ANN) are biologically inspired computer programs designed to simulate the way in which the human brain processes the information. In the past few years, coupling of experimental design (ED) and ANN became useful tool in the method optimization. This paper presents the application of ED-ANN in analysis of chromatographic behavior of indinavir and its degradation products. According to preliminary study, full factorial design 2(4) was chosen to set input variables for network training. Experimental data (inputs) and results for retention factors from experiments (outputs) were used to train the ANN with aim to define correlation among variables. For networks training multi-layer perceptron (MLP) with back propagation (BP) algorithm was used. Network with the lowest root mean square (RMS) had 4-8-3 topology. Predicted data were in good agreement with experimental data (correlation was higher than 0.9713 for training set). Regression statistics confirmed good ab...ility of trained network to predict compounds retention.

Keywords:
Experimental design / Artificial neural networks / Liquid chromatography / Indinavir / Degradation products
Source:
Talanta, 2009, 78, 1, 107-112
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Formulisanje i Karakterizacija separacionih sistema za modelovanje retencionog ponašanja lekovitih supstancija uz hemometrijsku evaluaciju (RS-142077)

DOI: 10.1016/j.talanta.2008.10.066

ISSN: 0039-9140

PubMed: 19174211

WoS: 000263634700016

Scopus: 2-s2.0-58649105768
[ Google Scholar ]
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11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1247
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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