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dc.creatorJančić-Stojanović, Biljana
dc.creatorMalenović, Anđelija
dc.creatorIvanović, D.
dc.creatorRakić, Tijana
dc.creatorMedenica, Mirjana
dc.date.accessioned2019-09-02T11:18:05Z
dc.date.available2019-09-02T11:18:05Z
dc.date.issued2009
dc.identifier.issn0021-9673
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1250
dc.description.abstractThe aim of this study was the chemometrical evaluation of ropinirole and its impurity's (4-[2(dipropylamino)ethyl]-1H-indol-2,3-dione) chromatographic behavior in systematic and the most efficient way. For that purpose, as very descriptive, response surface designs are most preferable. Face-centered central composite design (CCD) with 2(3) full factorial design, +/- 1 star design and four replication in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. Factors-independent variables (acetonitrile content, pH of the mobile phase and concentration of sodium heptane sulfonate in water phase) were extracted from the preliminary study and as dependent variables five responses (retention factor of ropinirole, retentin factor of its impurity, resolution, symmetry of ropinirole peak and symmetry of impurity peak) were selected. For the improvement of method development and optimization step, Derringer's desirability function was applied to simultaneously optimize the five chosen responses. The procedure allowed deduction of optimal conditions and the predicted optimum was acetonitrile-5 mM of sodium heptane sulfonate (21.6:78.4, v/v), pH of the mobile phase adjusted at 2.0 with ortho phosphoric acid. By calculating global desirability's determination coefficients (R-D(2)), as well as by the visual inspection of 3D graphs for global desirability, robustness of the proposed method was also estimated.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142077/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectRopinirole and its impurityen
dc.subjectCentral composite designen
dc.subjectMulticriteria decision makingen
dc.subjectDerringer's desirability functionen
dc.subjectRobustness testingen
dc.titleChemometrical evaluation of ropinirole and its impurity's chromatographic behavioren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРакић, Тијана; Меденица, Мирјана; Ивановић, Д.; Маленовић, Aнђелија; Јанчић-Стојановић, Биљана;
dc.citation.volume1216
dc.citation.issue8
dc.citation.spage1263
dc.citation.epage1269
dc.citation.other1216(8): 1263-1269
dc.citation.rankaM21
dc.identifier.wos000263740300007
dc.identifier.doi10.1016/j.chroma.2008.10.059
dc.identifier.pmid18976771
dc.identifier.scopus2-s2.0-58949097539
dc.identifier.rcubconv_2119
dc.type.versionpublishedVersion


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