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Could depression be a new branch of MIA syndrome?

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Authors
Simić-Ogrizović, Sanja
Jovanović, D.
Dopsaj, Violeta
Radović, M.
Šumarac, Zorica
Bogavac-Stanojević, Nataša
Stošović, Milan
Stanojević, M.
Nesić, V.
Article (Published version)
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Abstract
The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also ...found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome.

Keywords:
depression / inflammation / dialysis mortality / malnutrition, inflammation, atherosclerosis (MIA)
Source:
Clinical Nephrology, 2009, 71, 2, 164-172
Publisher:
  • Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
Projects:
  • Starenje i bolesti bubrega: razvoj strategije za rano otkrivanje, prevenciju i lečenje (RS-145043)

ISSN: 0301-0430

PubMed: 19203509

WoS: 000263907700009

Scopus: 2-s2.0-64549127855
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1251
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Pharmacy

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