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Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor

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1995
Authors
Sajc, L
Vunjak-Novaković, G
Grubišić, Dragoljub
Kovačević, Nada
Vuković, D
Bugarski, Branko
Article (Published version)
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Abstract
The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown higher production of anthraquinones in cell suspension and flask cultures of calcium-alginate-immobilized cells when silicone oil was incorporated into the medium, compared to a control without silicone oil. An external-loop air-lift bioreactor, developed and designed for the production and simultaneous extraction of extracellular plant cell products, was regarded as a four-phase system, with dispersed gas, non-aqueous solvent and calcium-alginate-immobilized plant cells in Murashige and Skoog medium. Continuous extraction of anthraquinones by silicone oil and n-hexadecane inside the bioreactor resulted in 10–30 times higher cell productivity, compared to that of immobilized cells in a flask. Based on the mixing pattern, immobilized biocatalyst extraparticle and intrapar...ticle diffusional constraints and the kinetics of growth, substrate consumption and product formation, a mathematical model was developed to describe the time course of a batch plant cell culture.

Source:
Applied Microbiology and Biotechnology, 1995, 43, 3, 416-423

DOI: 10.1007/BF00218443

ISSN: 0175-7598

Scopus: 2-s2.0-0029164342
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11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/126
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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