A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds.
TY - JOUR
AU - Rakić-Ignjatović, Anita
AU - Nikolić, Katarina
AU - Miljković, Branislava
AU - Pokrajac, Milena
AU - Agbaba, Danica
AU - Prostran, Milica
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1260
AB - A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds.
PB - Taylor & Francis Inc, Philadelphia
T2 - Journal of Liquid Chromatography & Related Technologies
T1 - Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study
VL - 32
IS - 14
SP - 2080
EP - 2096
DO - 10.1080/10826070903126963
ER -
@article{
author = "Rakić-Ignjatović, Anita and Nikolić, Katarina and Miljković, Branislava and Pokrajac, Milena and Agbaba, Danica and Prostran, Milica",
year = "2009",
abstract = "A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study",
volume = "32",
number = "14",
pages = "2080-2096",
doi = "10.1080/10826070903126963"
}
Rakić-Ignjatović, A., Nikolić, K., Miljković, B., Pokrajac, M., Agbaba, D.,& Prostran, M.. (2009). Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 32(14), 2080-2096.
https://doi.org/10.1080/10826070903126963
Rakić-Ignjatović A, Nikolić K, Miljković B, Pokrajac M, Agbaba D, Prostran M. Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study. in Journal of Liquid Chromatography & Related Technologies. 2009;32(14):2080-2096.
doi:10.1080/10826070903126963 .
Rakić-Ignjatović, Anita, Nikolić, Katarina, Miljković, Branislava, Pokrajac, Milena, Agbaba, Danica, Prostran, Milica, "Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study" in Journal of Liquid Chromatography & Related Technologies, 32, no. 14 (2009):2080-2096,
https://doi.org/10.1080/10826070903126963 . .
