Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study
Samo za registrovane korisnike
2009
Autori
Rakić-Ignjatović, AnitaNikolić, Katarina
Miljković, Branislava
Pokrajac, Milena
Agbaba, Danica
Prostran, Milica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds.
Ključne reči:
HPLC / Metabolites / Moclobemide / Plasma / QSRR model / SPEIzvor:
Journal of Liquid Chromatography & Related Technologies, 2009, 32, 14, 2080-2096Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Medicines and Medical Devices Agency of Serbia
DOI: 10.1080/10826070903126963
ISSN: 1082-6076
WoS: 000268832800008
Scopus: 2-s2.0-70349275472
Institucija/grupa
PharmacyTY - JOUR AU - Rakić-Ignjatović, Anita AU - Nikolić, Katarina AU - Miljković, Branislava AU - Pokrajac, Milena AU - Agbaba, Danica AU - Prostran, Milica PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1260 AB - A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study VL - 32 IS - 14 SP - 2080 EP - 2096 DO - 10.1080/10826070903126963 ER -
@article{ author = "Rakić-Ignjatović, Anita and Nikolić, Katarina and Miljković, Branislava and Pokrajac, Milena and Agbaba, Danica and Prostran, Milica", year = "2009", abstract = "A SPE-HPLC-UV method for determination of moclobemide and its major metabolites, Ro 12-5637 and Ro 12-8095, in human plasma had been developed previously and its selectivity was evaluated against the most frequently coadministered drugs. The objective of the present work was to develop a quantitative structure retention relationship (QSRR) model capable of providing good predictions of chromatographic behaviour of other related potentially interfering drugs, based on the previously generated data, in order to further improve the clinical applicability of the existing method. Moreover, the most critical factors affecting SPE and chromatographic separations of moclobemide and its metabolites were evaluated and discussed, taking into account molecular properties of the analyzed compounds.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study", volume = "32", number = "14", pages = "2080-2096", doi = "10.1080/10826070903126963" }
Rakić-Ignjatović, A., Nikolić, K., Miljković, B., Pokrajac, M., Agbaba, D.,& Prostran, M.. (2009). Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 32(14), 2080-2096. https://doi.org/10.1080/10826070903126963
Rakić-Ignjatović A, Nikolić K, Miljković B, Pokrajac M, Agbaba D, Prostran M. Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study. in Journal of Liquid Chromatography & Related Technologies. 2009;32(14):2080-2096. doi:10.1080/10826070903126963 .
Rakić-Ignjatović, Anita, Nikolić, Katarina, Miljković, Branislava, Pokrajac, Milena, Agbaba, Danica, Prostran, Milica, "Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study" in Journal of Liquid Chromatography & Related Technologies, 32, no. 14 (2009):2080-2096, https://doi.org/10.1080/10826070903126963 . .