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Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles

Authorized Users Only
2009
Authors
Cekić, Nebojša
Milić, Jela
Savić, Snežana
Savić, Miroslav
Jović, Žarko
Daniels, Rolf
Article (Published version)
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Abstract
Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted base...d on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.

Keywords:
Alginate-chitosan microparticles / phenytoin / physicochemical characterization / preparation / release behavior
Source:
Drug Development and Industrial Pharmacy, 2009, 35, 9, 1092-1102
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-142063)

DOI: 10.1080/03639040902774164

ISSN: 0363-9045

PubMed: 19365778

WoS: 000269927100009

Scopus: 2-s2.0-70350672557
[ Google Scholar ]
15
16
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1261
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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