FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization

Authorized Users Only
2009
Authors
Vujić, Zorica
Uskoković-Marković, Snežana
Kuntić, Vesna
Article (Published version)
Metadata
Show full item record
Abstract
A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.
Keywords:
Antidepressants / desipramine / maprotiline / moclobemide / pharmaceutical formulations / RP-HPLC / statistical optimization
Source:
Analytical Letters, 2009, 42, 13, 2060-2070
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Supstance za farmaceutsku upotrebu: modeliranje, sinteza, fizičko-hemijske i biološke osobine, stepen čistoće i ispitivanje doziranih oblika (RS-142072)

DOI: 10.1080/00032710903082747

ISSN: 0003-2719

WoS: 000269770400010

Scopus: 2-s2.0-70350005086
[ Google Scholar ]
2
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1266
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vujić, Zorica
AU  - Uskoković-Marković, Snežana
AU  - Kuntić, Vesna
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1266
AB  - A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Analytical Letters
T1  - Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization
VL  - 42
IS  - 13
SP  - 2060
EP  - 2070
DO  - 10.1080/00032710903082747
ER  - 
@article{
author = "Vujić, Zorica and Uskoković-Marković, Snežana and Kuntić, Vesna",
year = "2009",
abstract = "A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization",
volume = "42",
number = "13",
pages = "2060-2070",
doi = "10.1080/00032710903082747"
}
Vujić, Z., Uskoković-Marković, S.,& Kuntić, V.. (2009). Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 42(13), 2060-2070.
https://doi.org/10.1080/00032710903082747
Vujić Z, Uskoković-Marković S, Kuntić V. Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters. 2009;42(13):2060-2070.
doi:10.1080/00032710903082747 .
Vujić, Zorica, Uskoković-Marković, Snežana, Kuntić, Vesna, "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization" in Analytical Letters, 42, no. 13 (2009):2060-2070,
https://doi.org/10.1080/00032710903082747 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB