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Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization
A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.
TY - JOUR
AU - Vujić, Zorica
AU - Uskoković-Marković, Snežana
AU - Kuntić, Vesna
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1266
AB - A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.
PB - Taylor & Francis Inc, Philadelphia
T2 - Analytical Letters
T1 - Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization
VL - 42
IS - 13
SP - 2060
EP - 2070
DO - 10.1080/00032710903082747
ER -
@article{
author = "Vujić, Zorica and Uskoković-Marković, Snežana and Kuntić, Vesna",
year = "2009",
abstract = "A method for separation of three antidepressants, maprotiline, desipramine, and moclobemide, by reversed-phase high-performance liquid chromatography (RP-HPLC) was developed and validated. To find optimal conditions and estimate the impact of individual parameters on the separation, a complete set of 23 interdependent relationships of the mobile phase composition, temperature, and the volume flow rate were examined. Full separation of the investigated components from a laboratory mixture was achieved on a Supelcosil LC-18 (120mmx4.6mm, 5 mu m) column, using two solvent systems, 3% ammonium ion in water/ethanol and acetonitrile, and alternating isocratic gradient-isocratic elution modes. Relevance of the proposed method for therapeutic drug monitoring is anticipated.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Analytical Letters",
title = "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization",
volume = "42",
number = "13",
pages = "2060-2070",
doi = "10.1080/00032710903082747"
}
Vujić, Z., Uskoković-Marković, S.,& Kuntić, V.. (2009). Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters
Taylor & Francis Inc, Philadelphia., 42(13), 2060-2070.
https://doi.org/10.1080/00032710903082747
Vujić Z, Uskoković-Marković S, Kuntić V. Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization. in Analytical Letters. 2009;42(13):2060-2070.
doi:10.1080/00032710903082747 .
Vujić, Zorica, Uskoković-Marković, Snežana, Kuntić, Vesna, "Simultaneous Determination of Maprotiline, Desipramine, and Moclobemide by Reversed-Phase High-Performance Liquid Chromatography and Statistical Optimization" in Analytical Letters, 42, no. 13 (2009):2060-2070,
https://doi.org/10.1080/00032710903082747 . .
