Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance
Само за регистроване кориснике
2009
Аутори
Savić, SnežanaWeber, Christian
Tamburić, Slobodanka
Savić, Miroslav
Mueller-Goymann, Christel
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, wit...h incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.
Кључне речи:
natural surfactant / alkylpolyglucoside / mixed emulsifier / propylene glycol / glycerol / diclofenac sodium / caffeine / in vitro permeation / cytotoxicity assay / in vivo skin performanceИзвор:
Journal of Pharmaceutical Sciences, 2009, 98, 6, 2073-2090Издавач:
- Elsevier Science Inc, New York
DOI: 10.1002/jps.21591
ISSN: 0022-3549
PubMed: 18937361
WoS: 000266572600016
Scopus: 2-s2.0-67049165137
Институција/група
PharmacyTY - JOUR AU - Savić, Snežana AU - Weber, Christian AU - Tamburić, Slobodanka AU - Savić, Miroslav AU - Mueller-Goymann, Christel PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1272 AB - There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type. PB - Elsevier Science Inc, New York T2 - Journal of Pharmaceutical Sciences T1 - Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance VL - 98 IS - 6 SP - 2073 EP - 2090 DO - 10.1002/jps.21591 ER -
@article{ author = "Savić, Snežana and Weber, Christian and Tamburić, Slobodanka and Savić, Miroslav and Mueller-Goymann, Christel", year = "2009", abstract = "There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Pharmaceutical Sciences", title = "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance", volume = "98", number = "6", pages = "2073-2090", doi = "10.1002/jps.21591" }
Savić, S., Weber, C., Tamburić, S., Savić, M.,& Mueller-Goymann, C.. (2009). Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences Elsevier Science Inc, New York., 98(6), 2073-2090. https://doi.org/10.1002/jps.21591
Savić S, Weber C, Tamburić S, Savić M, Mueller-Goymann C. Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences. 2009;98(6):2073-2090. doi:10.1002/jps.21591 .
Savić, Snežana, Weber, Christian, Tamburić, Slobodanka, Savić, Miroslav, Mueller-Goymann, Christel, "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance" in Journal of Pharmaceutical Sciences, 98, no. 6 (2009):2073-2090, https://doi.org/10.1002/jps.21591 . .