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dc.creatorSavić, Snežana
dc.creatorWeber, Christian
dc.creatorTamburić, Slobodanka
dc.creatorSavić, Miroslav
dc.creatorMueller-Goymann, Christel
dc.date.accessioned2019-09-02T11:18:37Z
dc.date.available2019-09-02T11:18:37Z
dc.date.issued2009
dc.identifier.issn0022-3549
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1272
dc.description.abstractThere is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.en
dc.publisherElsevier Science Inc, New York
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectnatural surfactanten
dc.subjectalkylpolyglucosideen
dc.subjectmixed emulsifieren
dc.subjectpropylene glycolen
dc.subjectglycerolen
dc.subjectdiclofenac sodiumen
dc.subjectcaffeineen
dc.subjectin vitro permeationen
dc.subjectcytotoxicity assayen
dc.subjectin vivo skin performanceen
dc.titleTopical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performanceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractWебер, Цхристиан; Савић, Мирослав; Муеллер-Гоyманн, Цхристел; Тамбурић, Слободанка; Савић, Снежана;
dc.citation.volume98
dc.citation.issue6
dc.citation.spage2073
dc.citation.epage2090
dc.citation.other98(6): 2073-2090
dc.citation.rankM21
dc.identifier.wos000266572600016
dc.identifier.doi10.1002/jps.21591
dc.identifier.pmid18937361
dc.identifier.scopus2-s2.0-67049165137
dc.identifier.rcubconv_2152
dc.type.versionpublishedVersion


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