Show simple item record

dc.creatorPetrović, Aleksandra
dc.creatorIbrić, Svetlana
dc.creatorTrajković, Svetlana
dc.creatorPopović, Radmila
dc.creatorĐurić, Zorica
dc.creatorPopadić, Dragica
dc.date.accessioned2019-09-02T11:18:57Z
dc.date.available2019-09-02T11:18:57Z
dc.date.issued2009
dc.identifier.issn0253-6269
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1284
dc.description.abstractThe purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.en
dc.publisherPharmaceutical Soc Korea, Seoul
dc.relationMinistry of Science and Environmental Protection, Republic of Serbia - 6719B
dc.rightsrestrictedAccess
dc.sourceArchives of Pharmacal Research
dc.subjectSustained release dosage formen
dc.subjectIn vitro testsen
dc.subjectGeneral experimental designen
dc.subjectDissolutionen
dc.subjectDiffusion-erosion kineticsen
dc.titleAn investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial designen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТрајковић, Светлана; Ибрић, Светлана; Поповић, Радмила; Ђурић, Зорица; Петровић, Aлександра; Попадић, Драгица;
dc.citation.volume32
dc.citation.issue7
dc.citation.spage1087
dc.citation.epage1096
dc.citation.other32(7): 1087-1096
dc.citation.rankM23
dc.identifier.wos000268511000017
dc.identifier.doi10.1007/s12272-009-1715-y
dc.identifier.pmid19641891
dc.identifier.scopus2-s2.0-68649103530
dc.identifier.rcubconv_2184
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record