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Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia

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2009
Authors
Petrić, Marina
Tasić, Ljiljana
Sukljević, Stevan
Article (Published version)
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Abstract
This study assessed the utilization of prescription and over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) as well as the rate of self-medication with diclofenac, ibuprofen, and naproxen in the Braneechevo District of the Republic of Serbia. Estimation of gastrointestinal (GI) disease (morbidity) trends and GI toxicityassociated hospitalization were studied and direct costs due to NSAID-induced GI toxicity are presented. This descriptive, retrospective study addressed drug use and outcomes between 2004 and 2006 documented in the Health Insurance Fund database of the Pozarevac Public Pharmacy in the Pozarevac Public Health Centar of the Braneechevo District, which includes 200,503 inhabitants. Data type/selection were defined daily doses (DDD) per 1000 inhabitants per day for utilization of drugs, number of patients with ICD-9 diagnosis codes for GI disorders; GI hospitalization count (average annualy length of stay [in days] and number of GI hospitalizations); direct ...cost of hospital care. The OTC diclofenac use showed an increasing tendency: 6.2279; 6.5983; 8.2911 DDD units, as well as the utilization of OTC ibuprofen: 2.4389, 2.4899, 2.5776 DDD units, respectively (20042006), whereas OTC naproxen had relatively low utilization. In the same period, GI morbidity decreased: 9636, 7982, 7806, respectively, and the number of GI morbidity-associated hospitalizations increased 10.18% in 2005 and 15.06%, in versus 2004. The costs of GI morbidity-associated hospitalizations increased: 12.20% (2005) and 94.51% (2006), compared to 2004 costs with a positive correlation between utility of diclofenac and ibuprofen (self medication) and increased GI hospitalizations in Braneechevo.

Keywords:
Costs / Gastrointestinal (GI) / Nonsteroidal anti-inflammatory drugs (NSAIDs / Diclofenac / Ibuprofen / Naproxen) / Over-the-counter (OTC) / Serbia / Utlization
Source:
Journal of Pain and Palliative Care Pharmacotherapy, 2009, 23, 1, 40-47

DOI: 10.1080/15360280902728203

ISSN: 1536-0288

Scopus: 2-s2.0-67649541271
[ Google Scholar ]
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1290
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Petrić, Marina
AU  - Tasić, Ljiljana
AU  - Sukljević, Stevan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1290
AB  - This study assessed the utilization of prescription and over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) as well as the rate of self-medication with diclofenac, ibuprofen, and naproxen in the Braneechevo District of the Republic of Serbia. Estimation of gastrointestinal (GI) disease (morbidity) trends and GI toxicityassociated hospitalization were studied and direct costs due to NSAID-induced GI toxicity are presented. This descriptive, retrospective study addressed drug use and outcomes between 2004 and 2006 documented in the Health Insurance Fund database of the Pozarevac Public Pharmacy in the Pozarevac Public Health Centar of the Braneechevo District, which includes 200,503 inhabitants. Data type/selection were defined daily doses (DDD) per 1000 inhabitants per day for utilization of drugs, number of patients with ICD-9 diagnosis codes for GI disorders; GI hospitalization count (average annualy length of stay [in days] and number of GI hospitalizations); direct cost of hospital care. The OTC diclofenac use showed an increasing tendency: 6.2279; 6.5983; 8.2911 DDD units, as well as the utilization of OTC ibuprofen: 2.4389, 2.4899, 2.5776 DDD units, respectively (20042006), whereas OTC naproxen had relatively low utilization. In the same period, GI morbidity decreased: 9636, 7982, 7806, respectively, and the number of GI morbidity-associated hospitalizations increased 10.18% in 2005 and 15.06%, in versus 2004. The costs of GI morbidity-associated hospitalizations increased: 12.20% (2005) and 94.51% (2006), compared to 2004 costs with a positive correlation between utility of diclofenac and ibuprofen (self medication) and increased GI hospitalizations in Braneechevo.
T2  - Journal of Pain and Palliative Care Pharmacotherapy
T1  - Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia
VL  - 23
IS  - 1
SP  - 40
EP  - 47
DO  - 10.1080/15360280902728203
ER  - 
@article{
author = "Petrić, Marina and Tasić, Ljiljana and Sukljević, Stevan",
year = "2009",
abstract = "This study assessed the utilization of prescription and over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) as well as the rate of self-medication with diclofenac, ibuprofen, and naproxen in the Braneechevo District of the Republic of Serbia. Estimation of gastrointestinal (GI) disease (morbidity) trends and GI toxicityassociated hospitalization were studied and direct costs due to NSAID-induced GI toxicity are presented. This descriptive, retrospective study addressed drug use and outcomes between 2004 and 2006 documented in the Health Insurance Fund database of the Pozarevac Public Pharmacy in the Pozarevac Public Health Centar of the Braneechevo District, which includes 200,503 inhabitants. Data type/selection were defined daily doses (DDD) per 1000 inhabitants per day for utilization of drugs, number of patients with ICD-9 diagnosis codes for GI disorders; GI hospitalization count (average annualy length of stay [in days] and number of GI hospitalizations); direct cost of hospital care. The OTC diclofenac use showed an increasing tendency: 6.2279; 6.5983; 8.2911 DDD units, as well as the utilization of OTC ibuprofen: 2.4389, 2.4899, 2.5776 DDD units, respectively (20042006), whereas OTC naproxen had relatively low utilization. In the same period, GI morbidity decreased: 9636, 7982, 7806, respectively, and the number of GI morbidity-associated hospitalizations increased 10.18% in 2005 and 15.06%, in versus 2004. The costs of GI morbidity-associated hospitalizations increased: 12.20% (2005) and 94.51% (2006), compared to 2004 costs with a positive correlation between utility of diclofenac and ibuprofen (self medication) and increased GI hospitalizations in Braneechevo.",
journal = "Journal of Pain and Palliative Care Pharmacotherapy",
title = "Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia",
volume = "23",
number = "1",
pages = "40-47",
doi = "10.1080/15360280902728203"
}
Petrić, M., Tasić, L.,& Sukljević, S.. (2009). Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia. in Journal of Pain and Palliative Care Pharmacotherapy, 23(1), 40-47.
https://doi.org/10.1080/15360280902728203
Petrić M, Tasić L, Sukljević S. Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia. in Journal of Pain and Palliative Care Pharmacotherapy. 2009;23(1):40-47.
doi:10.1080/15360280902728203 .
Petrić, Marina, Tasić, Ljiljana, Sukljević, Stevan, "Nonsteroidal anti-inflammatory drug usage and gastrointestinal outcomes in the Republic of Serbia" in Journal of Pain and Palliative Care Pharmacotherapy, 23, no. 1 (2009):40-47,
https://doi.org/10.1080/15360280902728203 . .

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