FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita

Thumbnail
2009
1292.pdf (1.190Mb)
Authors
Odović, Jadranka
Aleksić, Mirjana
Stojimirović, Biljana
Milojković-Opsenica, Dušanka
Tešić, Živoslav
Article (Published version)
Metadata
Show full item record
Abstract
The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.
Keywords:
ACE inhibitors / normal-phase thin-layer chromatography / hydrophobicity
Source:
Journal of the Serbian Chemical Society, 2009, 74, 6, 677-688
Publisher:
  • Srpsko hemijsko društvo, Beograd
Funding / projects:
  • Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)

DOI: 10.2298/JSC0906677O

ISSN: 0352-5139

WoS: 000268739700008

Scopus: 2-s2.0-68949110533
[ Google Scholar ]
17
16
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1294
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Odović, Jadranka
AU  - Aleksić, Mirjana
AU  - Stojimirović, Biljana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1294
AB  - The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
AB  - Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites
T1  - Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita
VL  - 74
IS  - 6
SP  - 677
EP  - 688
DO  - 10.2298/JSC0906677O
ER  - 
@article{
author = "Odović, Jadranka and Aleksić, Mirjana and Stojimirović, Biljana and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2009",
abstract = "The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography., Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites, Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita",
volume = "74",
number = "6",
pages = "677-688",
doi = "10.2298/JSC0906677O"
}
Odović, J., Aleksić, M., Stojimirović, B., Milojković-Opsenica, D.,& Tešić, Ž.. (2009). Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 74(6), 677-688.
https://doi.org/10.2298/JSC0906677O
Odović J, Aleksić M, Stojimirović B, Milojković-Opsenica D, Tešić Ž. Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society. 2009;74(6):677-688.
doi:10.2298/JSC0906677O .
Odović, Jadranka, Aleksić, Mirjana, Stojimirović, Biljana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites" in Journal of the Serbian Chemical Society, 74, no. 6 (2009):677-688,
https://doi.org/10.2298/JSC0906677O . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB