Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites
Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita

2009
Authors
Odović, Jadranka
Aleksić, Mirjana
Stojimirović, Biljana
Milojković-Opsenica, Dušanka

Tešić, Živoslav

Article (Published version)
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The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.
Keywords:
ACE inhibitors / normal-phase thin-layer chromatography / hydrophobicitySource:
Journal of the Serbian Chemical Society, 2009, 74, 6, 677-688Publisher:
- Srpsko hemijsko društvo, Beograd
Funding / projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)
DOI: 10.2298/JSC0906677O
ISSN: 0352-5139
WoS: 000268739700008
Scopus: 2-s2.0-68949110533
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Institution/Community
PharmacyTY - JOUR AU - Odović, Jadranka AU - Aleksić, Mirjana AU - Stojimirović, Biljana AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1294 AB - The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography. AB - Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites T1 - Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita VL - 74 IS - 6 SP - 677 EP - 688 DO - 10.2298/JSC0906677O ER -
@article{ author = "Odović, Jadranka and Aleksić, Mirjana and Stojimirović, Biljana and Milojković-Opsenica, Dušanka and Tešić, Živoslav", year = "2009", abstract = "The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography., Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites, Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita", volume = "74", number = "6", pages = "677-688", doi = "10.2298/JSC0906677O" }
Odović, J., Aleksić, M., Stojimirović, B., Milojković-Opsenica, D.,& Tešić, Ž.. (2009). Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 74(6), 677-688. https://doi.org/10.2298/JSC0906677O
Odović J, Aleksić M, Stojimirović B, Milojković-Opsenica D, Tešić Ž. Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society. 2009;74(6):677-688. doi:10.2298/JSC0906677O .
Odović, Jadranka, Aleksić, Mirjana, Stojimirović, Biljana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites" in Journal of the Serbian Chemical Society, 74, no. 6 (2009):677-688, https://doi.org/10.2298/JSC0906677O . .