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Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites
Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita
dc.creator | Odović, Jadranka | |
dc.creator | Aleksić, Mirjana | |
dc.creator | Stojimirović, Biljana | |
dc.creator | Milojković-Opsenica, Dušanka | |
dc.creator | Tešić, Živoslav | |
dc.date.accessioned | 2019-09-02T11:19:11Z | |
dc.date.available | 2019-09-02T11:19:11Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1294 | |
dc.description.abstract | The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography. | en |
dc.description.abstract | Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije. | sr |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | ACE inhibitors | en |
dc.subject | normal-phase thin-layer chromatography | en |
dc.subject | hydrophobicity | en |
dc.title | Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites | en |
dc.title | Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Стојимировић, Биљана; Милојковић-Опсеница, Душанка; Тешић, Живослав; Aлексић, Мирјана; Одовић, Јадранка; Нормално-фазна танкослојна хроматографија неких AЦЕ инхибитора и њихових метаболита; Нормално-фазна танкослојна хроматографија неких AЦЕ инхибитора и њихових метаболита; | |
dc.citation.volume | 74 | |
dc.citation.issue | 6 | |
dc.citation.spage | 677 | |
dc.citation.epage | 688 | |
dc.citation.other | 74(6): 677-688 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000268739700008 | |
dc.identifier.doi | 10.2298/JSC0906677O | |
dc.identifier.scopus | 2-s2.0-68949110533 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/224/1292.pdf | |
dc.type.version | publishedVersion |