Tungstates and polyoxotungstates have been known to be bioactive compounds for a long time. Based on our previous work about sodium tungstate (ST) and 12-tungstophosphoric acid (WPA) as hepatoprotective agents, we performed a seven week long experiment in rats, using ST and WPA pretreatments in thioacetamide (TAA) induced acute liver necrosis. The possible influences of dimethyl sulfoxide (DMSO), given orally for 3 consecutive days before inducing hepatic lesions, were also investigated. The effects were evaluated by the activity of serum enzymes, oxidative stress parameters, antioxidative defense markers, and histopathology in Wistar rats. The obtained results suggest that oral pretreatment with tungstates, especially ST, in combination with DMSO, before the TAA inducted liver necrosis, could be useful for the prevention of hepatic injury in rats.
Volframati i polioksovolframati su decenijama poznati kao biološki aktivna jedinjenja. Kao nastavak prethodnog istraživanja hepatoprotektivnog efekta natrijum volframata (ST) i 12-volframfosforne kiseline (WPA), izveden je eksperiment na Wistar pacovima, koji su pretretirani sa ST i WPA tokom sedam nedelja a nakon tog perioda im je intraperitonealno ubrizgan tioacetamid (TAA) u cilju indukovanja akutne nekroze jetre. Ispitivan je uticaj dimetil sulfoksida (DMSO), koji je primenjivan per os u toku 3 konsekutativna dana pre indukcije hepatične nekroze. Efekti su evaluirani praćenjem aktivnosti serumskih enzima, parametara oksidativnog stresa, antioksidativnog odbrambenog markera, kao i histopatološkom analizom tkiva jetre. Dobijeni rezultati ukazuju da oralni pretretman pacova sa volframatima, pre svega ST, u kombinaciji sa DMSO, može biti koristan u prevenciji nekroze jetre indukovane tioacetamidom.
TY - JOUR
AU - Uskoković-Marković, Snežana
AU - Milenković, Marina
AU - Topić, Aleksandra
AU - Kotur-Stevuljević, Jelena
AU - Stefanović, Aleksandra
AU - Antić-Stanković, Jelena
AU - Holclajtner-Antunović, Ivanka
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1312
AB - Tungstates and polyoxotungstates have been known to be bioactive compounds for a long time. Based on our previous work about sodium tungstate (ST) and 12-tungstophosphoric acid (WPA) as hepatoprotective agents, we performed a seven week long experiment in rats, using ST and WPA pretreatments in thioacetamide (TAA) induced acute liver necrosis. The possible influences of dimethyl sulfoxide (DMSO), given orally for 3 consecutive days before inducing hepatic lesions, were also investigated. The effects were evaluated by the activity of serum enzymes, oxidative stress parameters, antioxidative defense markers, and histopathology in Wistar rats. The obtained results suggest that oral pretreatment with tungstates, especially ST, in combination with DMSO, before the TAA inducted liver necrosis, could be useful for the prevention of hepatic injury in rats.
AB - Volframati i polioksovolframati su decenijama poznati kao biološki aktivna jedinjenja. Kao nastavak prethodnog istraživanja hepatoprotektivnog efekta natrijum volframata (ST) i 12-volframfosforne kiseline (WPA), izveden je eksperiment na Wistar pacovima, koji su pretretirani sa ST i WPA tokom sedam nedelja a nakon tog perioda im je intraperitonealno ubrizgan tioacetamid (TAA) u cilju indukovanja akutne nekroze jetre. Ispitivan je uticaj dimetil sulfoksida (DMSO), koji je primenjivan per os u toku 3 konsekutativna dana pre indukcije hepatične nekroze. Efekti su evaluirani praćenjem aktivnosti serumskih enzima, parametara oksidativnog stresa, antioksidativnog odbrambenog markera, kao i histopatološkom analizom tkiva jetre. Dobijeni rezultati ukazuju da oralni pretretman pacova sa volframatima, pre svega ST, u kombinaciji sa DMSO, može biti koristan u prevenciji nekroze jetre indukovane tioacetamidom.
PB - Savez farmaceutskih udruženja Srbije, Beograd
T2 - Arhiv za farmaciju
T1 - Beneficial effects of dimethyl sulfoxide on tungstates hepatoprotecitve activity
T1 - Pozitivan učinak dimetilsulfoksida na hepatoprotektivnu aktivnost volframata
VL - 59
IS - 4
SP - 265
EP - 278
UR - https://hdl.handle.net/21.15107/rcub_farfar_1312
ER -
@article{
author = "Uskoković-Marković, Snežana and Milenković, Marina and Topić, Aleksandra and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Antić-Stanković, Jelena and Holclajtner-Antunović, Ivanka",
year = "2009",
abstract = "Tungstates and polyoxotungstates have been known to be bioactive compounds for a long time. Based on our previous work about sodium tungstate (ST) and 12-tungstophosphoric acid (WPA) as hepatoprotective agents, we performed a seven week long experiment in rats, using ST and WPA pretreatments in thioacetamide (TAA) induced acute liver necrosis. The possible influences of dimethyl sulfoxide (DMSO), given orally for 3 consecutive days before inducing hepatic lesions, were also investigated. The effects were evaluated by the activity of serum enzymes, oxidative stress parameters, antioxidative defense markers, and histopathology in Wistar rats. The obtained results suggest that oral pretreatment with tungstates, especially ST, in combination with DMSO, before the TAA inducted liver necrosis, could be useful for the prevention of hepatic injury in rats., Volframati i polioksovolframati su decenijama poznati kao biološki aktivna jedinjenja. Kao nastavak prethodnog istraživanja hepatoprotektivnog efekta natrijum volframata (ST) i 12-volframfosforne kiseline (WPA), izveden je eksperiment na Wistar pacovima, koji su pretretirani sa ST i WPA tokom sedam nedelja a nakon tog perioda im je intraperitonealno ubrizgan tioacetamid (TAA) u cilju indukovanja akutne nekroze jetre. Ispitivan je uticaj dimetil sulfoksida (DMSO), koji je primenjivan per os u toku 3 konsekutativna dana pre indukcije hepatične nekroze. Efekti su evaluirani praćenjem aktivnosti serumskih enzima, parametara oksidativnog stresa, antioksidativnog odbrambenog markera, kao i histopatološkom analizom tkiva jetre. Dobijeni rezultati ukazuju da oralni pretretman pacova sa volframatima, pre svega ST, u kombinaciji sa DMSO, može biti koristan u prevenciji nekroze jetre indukovane tioacetamidom.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Beneficial effects of dimethyl sulfoxide on tungstates hepatoprotecitve activity, Pozitivan učinak dimetilsulfoksida na hepatoprotektivnu aktivnost volframata",
volume = "59",
number = "4",
pages = "265-278",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1312"
}
Uskoković-Marković, S., Milenković, M., Topić, A., Kotur-Stevuljević, J., Stefanović, A., Antić-Stanković, J.,& Holclajtner-Antunović, I.. (2009). Beneficial effects of dimethyl sulfoxide on tungstates hepatoprotecitve activity. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 59(4), 265-278.
https://hdl.handle.net/21.15107/rcub_farfar_1312
Uskoković-Marković S, Milenković M, Topić A, Kotur-Stevuljević J, Stefanović A, Antić-Stanković J, Holclajtner-Antunović I. Beneficial effects of dimethyl sulfoxide on tungstates hepatoprotecitve activity. in Arhiv za farmaciju. 2009;59(4):265-278.
https://hdl.handle.net/21.15107/rcub_farfar_1312 .
Uskoković-Marković, Snežana, Milenković, Marina, Topić, Aleksandra, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Antić-Stanković, Jelena, Holclajtner-Antunović, Ivanka, "Beneficial effects of dimethyl sulfoxide on tungstates hepatoprotecitve activity" in Arhiv za farmaciju, 59, no. 4 (2009):265-278,
https://hdl.handle.net/21.15107/rcub_farfar_1312 .
