This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.
TY - JOUR
AU - Odović, Jadranka
AU - Trbojević-Stanković, Jasna
PY - 2009
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1321
AB - This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
AB - U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.
PB - Savez hemijskih inženjera, Beograd
T2 - Hemijska industrija
T1 - Chromatography methods in investigation of lipophilicity of the biological active substances
T1 - Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci
VL - 63
IS - 1
SP - 33
EP - 37
DO - 10.2298/HEMIND0901033O
ER -
@article{
author = "Odović, Jadranka and Trbojević-Stanković, Jasna",
year = "2009",
abstract = "This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role., U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Chromatography methods in investigation of lipophilicity of the biological active substances, Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci",
volume = "63",
number = "1",
pages = "33-37",
doi = "10.2298/HEMIND0901033O"
}
Odović, J.,& Trbojević-Stanković, J.. (2009). Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 63(1), 33-37.
https://doi.org/10.2298/HEMIND0901033O
Odović J, Trbojević-Stanković J. Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija. 2009;63(1):33-37.
doi:10.2298/HEMIND0901033O .
Odović, Jadranka, Trbojević-Stanković, Jasna, "Chromatography methods in investigation of lipophilicity of the biological active substances" in Hemijska industrija, 63, no. 1 (2009):33-37,
https://doi.org/10.2298/HEMIND0901033O . .
