FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Chromatography methods in investigation of lipophilicity of the biological active substances

Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci

Thumbnail
2009
1319.pdf (263.7Kb)
Authors
Odović, Jadranka
Trbojević-Stanković, Jasna
Article (Published version)
Metadata
Show full item record
Abstract
This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.
Keywords:
lipophilicity / hydrophobicity / shake flask method / high performance liquid chromatography / thin layer chromatography / lipofilnost / hidrofobnost / shake flask metoda / visoko-efikasna tečna hromatografija / tankoslojna hromatografija
Source:
Hemijska industrija, 2009, 63, 1, 33-37
Publisher:
  • Savez hemijskih inženjera, Beograd

DOI: 10.2298/HEMIND0901033O

ISSN: 0367-598X

WoS: 000265518900004

Scopus: 2-s2.0-77952912827
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1321
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Odović, Jadranka
AU  - Trbojević-Stanković, Jasna
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1321
AB  - This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
AB  - U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Chromatography methods in investigation of lipophilicity of the biological active substances
T1  - Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci
VL  - 63
IS  - 1
SP  - 33
EP  - 37
DO  - 10.2298/HEMIND0901033O
ER  - 
@article{
author = "Odović, Jadranka and Trbojević-Stanković, Jasna",
year = "2009",
abstract = "This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role., U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Chromatography methods in investigation of lipophilicity of the biological active substances, Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci",
volume = "63",
number = "1",
pages = "33-37",
doi = "10.2298/HEMIND0901033O"
}
Odović, J.,& Trbojević-Stanković, J.. (2009). Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 63(1), 33-37.
https://doi.org/10.2298/HEMIND0901033O
Odović J, Trbojević-Stanković J. Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija. 2009;63(1):33-37.
doi:10.2298/HEMIND0901033O .
Odović, Jadranka, Trbojević-Stanković, Jasna, "Chromatography methods in investigation of lipophilicity of the biological active substances" in Hemijska industrija, 63, no. 1 (2009):33-37,
https://doi.org/10.2298/HEMIND0901033O . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB