Chromatography methods in investigation of lipophilicity of the biological active substances
Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci
Апстракт
This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role.
U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.
Кључне речи:
lipophilicity / hydrophobicity / shake flask method / high performance liquid chromatography / thin layer chromatography / lipofilnost / hidrofobnost / shake flask metoda / visoko-efikasna tečna hromatografija / tankoslojna hromatografijaИзвор:
Hemijska industrija, 2009, 63, 1, 33-37Издавач:
- Savez hemijskih inženjera, Beograd
DOI: 10.2298/HEMIND0901033O
ISSN: 0367-598X
WoS: 000265518900004
Scopus: 2-s2.0-77952912827
Институција/група
PharmacyTY - JOUR AU - Odović, Jadranka AU - Trbojević-Stanković, Jasna PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1321 AB - This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role. AB - U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto. PB - Savez hemijskih inženjera, Beograd T2 - Hemijska industrija T1 - Chromatography methods in investigation of lipophilicity of the biological active substances T1 - Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci VL - 63 IS - 1 SP - 33 EP - 37 DO - 10.2298/HEMIND0901033O ER -
@article{ author = "Odović, Jadranka and Trbojević-Stanković, Jasna", year = "2009", abstract = "This paper presents the review of the methods used in research of the biological active substances hydrophobicity, a very important property. The biological activity of some substances depends on their pharmacokinetics and pharmacodynamics. These processes depend on the molecule's capability to interact with two different media: aqueous (cells interior) and non-aqueous (cells membrane), or on the molecule lipophilicity. Today, great attention is given to investigation and systematic determination of drugs lipophilicity. In these researches chromatography methods have an important role., U ovom radu dat je pregled metoda koje nalaze primenu u proučavanju hidrofobnosti biološki aktivnih supstanci, što je njihova veoma značajna osobina. Biološka aktivnost neke supstance uslovljena je procesima njene farmakokinetike i farmakodinamike, koji zavise od sposobnosti molekula da interaguje sa dve različite sredine: nevodenom (ćelijska membrana) i vodenom (unutrašnjost ćelije), odnosno od njegove lipofilnosti. Danas se velika pažnja pridaje proučavanju i sistematskom određivanju lipofilnosti lekovitih supstanci. U ovim ispitivanjima hromatografske metode zauzimaju značajno mesto.", publisher = "Savez hemijskih inženjera, Beograd", journal = "Hemijska industrija", title = "Chromatography methods in investigation of lipophilicity of the biological active substances, Hromatografske metode u proučavanju lipofilnosti biološki aktivnih supstanci", volume = "63", number = "1", pages = "33-37", doi = "10.2298/HEMIND0901033O" }
Odović, J.,& Trbojević-Stanković, J.. (2009). Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija Savez hemijskih inženjera, Beograd., 63(1), 33-37. https://doi.org/10.2298/HEMIND0901033O
Odović J, Trbojević-Stanković J. Chromatography methods in investigation of lipophilicity of the biological active substances. in Hemijska industrija. 2009;63(1):33-37. doi:10.2298/HEMIND0901033O .
Odović, Jadranka, Trbojević-Stanković, Jasna, "Chromatography methods in investigation of lipophilicity of the biological active substances" in Hemijska industrija, 63, no. 1 (2009):33-37, https://doi.org/10.2298/HEMIND0901033O . .